Effects of Cyclic Tensile Forces on the Strength of Fibrous Tissue Examined in an in Vivo Model

DOI Web Site Web Site 17 References
  • TAKAKUDA Kazuo
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • KOYAMA Yoshihisa
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • MATSUMOTO Hiroko N.
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • KATAKURA Hiroshi
    School of Bionics, Tokyo University of Technology
  • MUNETA Takeshi
    Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University

Search this article

Abstract

Adaptive remodeling of soft fibrous tissues under cyclic tensile forces was investigated. Patellar tendons of rat’s knee were harvested and mounted on apparatuses for mechanical stimuli. They were transplanted into the subcutaneous tissues and experienced mechanical stimuli of cyclic tensile forces (1N, 1Hz). Then the tendons were retrieved and their mechanical properties were evaluated with a tensile tester. Four experimental groups were examined in which loading conditions were (1) three times a day (2700 cycles a day) throughout 4 weeks, (2) twice a week (1800 cycles a week) throughout 4 weeks, (3) load-free throughout 4 weeks, or (4) control. Comparing to control group, the tendons in load-free conditions were very weak and shown statistically significant decrease in maximum load, strength and tangent modulus. Contrarily, the tendons in frequent loadings (three times a day) nearly maintained their mechanical properties. Thus the present study clearly elucidated the fact that cyclic tensile forces have significant effects on the mechanical properties of transplanted fibrous tissues.

Journal

References(17)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top