Hemoglobin Adducts as a Marker of Exposure to Chemical Substances, Especially PRTR Class I Designated Chemical Substances

• Ogawa Masanori

  Department of Environmental Health, University of Occupational and Environmental Health Clinical Research Center for Occupational Poisoning, Tokyo Rosai Hospital

• Oyama Tsunehiro

  Department of Environmental Health, University of Occupational and Environmental Health

• Isse Toyohi

  Department of Environmental Health, University of Occupational and Environmental Health

• Yamaguchi Tetsunosuke

  Department of Environmental Health, University of Occupational and Environmental Health

• Murakami Tomoe

  Department of Environmental Health, University of Occupational and Environmental Health

• Endo Yoko

  Clinical Research Center for Occupational Poisoning, Tokyo Rosai Hospital

• Kawamoto Toshihiro

  Department of Environmental Health, University of Occupational and Environmental Health

抄録

Many new biomarkers are being studied, in addition to classical biomarkers, such as chemical substances and their metabolites in blood and urine and modified enzymes. Among these new biomarkers, hemoglobin adducts are thought to be especially useful for the estimation of chemical exposures. We review here the use of biomarkers for monitoring exposures to nine substances, mainly focusing on PRTR class I designated chemical substances, styrene, phenyloxirane (styrene oxide), 4,4'-methylendiphenyl diisocyanate (MDI), 4,4'-methylendianiline (MDA), 1,3-butadiene, ethylene oxide, propylene oxide, acrylamide and acrylonitrile. Hemoglobin adduct levels were elevated after exposures to styrene, MDI, MDA, 1, 3-butadiene, ethylene oxide, acrylamide and acrylonitrile. Moreover, hemoglobin adducts of butadiene, ethylene oxide, acrylamide and acrylonitrile have several useful advantages. For example, the hemoglobin adduct of 1,3-butadiene is an even more useful biomarker of exposure than urinary metabolites, and in the case of ethylene oxide, even though the concentration of ethylene oxide-Hb in the blood of workers did not exceed the value of the German exposure equivalent, a significant difference in it was found between workers and a control group. Also hemoglobin adducts of acrylamide and acrylonitrile can reflect their exposures because there are no urinary metabolites of acrylamide and acrylonitrile that are useful for exposure assessment. In addition to these advantages, hemoglobin adducts are superior to DNA adducts with respect to the availability of large amounts, availability of methods for chemical identification, and well-defined life spans due to the absence of repair. Hemoglobin adducts can be effective biomarkers for assessing exposure to and the effects of chemicals.<br>

収録刊行物

• ｊｏｕｒｎａｌ　ｏｆ　Ｏｃｃｕｐａｔｉｏｎａｌ　Ｈｅａｌｔｈ

  ｊｏｕｒｎａｌ　ｏｆ　Ｏｃｃｕｐａｔｉｏｎａｌ　Ｈｅａｌｔｈ 48 (5), 314-328, 2006

  公益社団法人 日本産業衛生学会

キーワード

• Hemoglobin adduct
• Biomarker
• Exposure assessment

詳細情報

• CRID: 1390282679433472640
• NII論文ID: 130004447354
• NII論文ID: 110004821575
• NII書誌ID: AA11090645
• DOI: 10.1539/joh.48.314
• ISSN: 13489585
• ISSN: 13419145
• NDL書誌ID: 8079660
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8079660
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1539%2Fjoh.48.314
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1539/joh.48.314
• Web Site: https://search.jamas.or.jp/link/ui/2007213751
• 本文言語コード: en
• データソース種別:
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