Effects of aging on .ALPHA.1-adrenoceptor mechanisms in the isolated mouse aortic preparation

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  • Tanaka Yoshio
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
  • Funabiki Midori
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
  • Michikawa Hiromi
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
  • Koike Katsuo
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences

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Abstract

The effects of aging on α1-adrenoceptor (α1-AR)-mediated contractile response in endothelium-removed aortic preparations isolated from 5- to 40-week-old (5-, 6-, 8-, 10-, 20-, 40-weeks) mice were studied in the presence of propranolol. The potency of noradrenaline, estimated as its pD2 value, increased with age from 5- to 10-weeks, but decreased thereafter with age from 10- to 40-weeks. However, the affinity of prazosin (pA2 value) did not change with aging. These results suggest that age-related change in noradrenaline potency is not attributable to the change of drug affinity to α1-ARs, but is possibly due to drug affinity-unrelated factors such as change of the reserve of α1-ARs.<br>

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