Antinociceptive, Anti-inflammatory and Antipyretic Effects of Solanum nigrum Chloroform Extract in Animal Models

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Abstract

  AIM: The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of chloroform extract of <i>Solanum nigrum</i> leaves using various animal models. METHODS: The extract was prepared by soaking (1:20; w/v) the air-dried powdered leaves (20 g) in chloroform for 72 hrs followed by evaporation (40°C) under reduced pressure to dryness (1.26 g) and then dissolved (1:50; w/v) in dimethylsulfoxide (DMSO). The supernatant, considered as the stock solution with dose of 200 mg/kg, was diluted using DMSO to 20 and 100 mg/kg, and all doses were administered (<i>s.c</i>.; 10 ml/kg) in mice/rats 30 min prior to tests. RESULTS: The extract exhibited significant (<i>p</i><0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (<i>p</i><0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests. Overall, the activities occurred in a dose-independent manner. CONCLUSION: The present study demonstrated that the lipid-soluble extract of <i>S. nigrum</i> leaves possessed antinociceptive, anti-inflammatory and anti-pyretic properties and confirmed the traditional claims.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 126(11), 1171-1178, 2006-11-01

    The Pharmaceutical Society of Japan

References:  55

Cited by:  1

Codes

  • NII Article ID (NAID)
    110004857378
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00316903
  • NDL Article ID
    8560577
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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