乳児期から思春期までの小児におけるスギ花粉感作の実態  [in Japanese] PREVALENCE OF SENSITIZATION OF JAPANESE CEDAR POLLEN IN CHILDREN FROM INFANCY TO ADOLESCENCE  [in Japanese]

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Abstract

【背景】近年,小児スギ花粉症の増加が指摘されている.しかし幼小児でのスギへの感作と花粉症発症の状況はよく解っていない.そこで,乳児から思春期までの小児のスギ花粉感作状況の調査を行った.【方法】243名のアレルギー疾患をもつ小児(8カ月〜16歳,中央値5歳)と137名の同疾患をもたない児(1カ月〜15歳,中央値4歳)についてスギ花粉,ヤケヒョウヒダニ,カモガヤ花粉,卵白,牛乳の血清中特異IgE抗体をCAP-RAST法で測定し,保護者記載による問診票とともに検討した.【結果】スギCAP-RAST陽性率はアレルギー疾患群で47.1%,非アレルギー疾患群で19.9%であった.スギ陽性率はアレルギー疾患群では3歳から5歳で急激に高くなっており,非アレルギー疾患群では幼児期から思春期にかけて徐々に増加していた.最年少のスギ陽性者は1歳11カ月のアトピー性皮膚炎男児であった.スギ陽性群では陰性群に比べ1〜3月生まれが占める割合が有意に高く,吸入抗原(ダニ,カモガヤ)の重複感作率が高かった.【結語】小児のスギ感作は就学前に成立するものが多い.今後,感作を回避するために乳幼児期からいかなる対策を立てていけばよいのか検討が必要である.

Background: In Japan, morbidity of Japanese cedar pollinosis has dramatically increased, especially in children. However, little is known about the prevalence of pollinosis and sensitization to Japanese cedar pollen (JCP) in young children. Objective: The aim of this study is to investigate the prevalence of sensitization to JCP in allergic and nonallergic children from infancy to adolescence. Methods: Two hundred forty three children with allergic diseases (age 8 months-16 years, mean 5 years) and 137 children without allergic diseases (age 1 month-15 years, mean 4 years) were recruited. Their specific IgE to JCP, house dust mite, orchard grass pollen, egg white, and milk were measured with the CAP-RAST system. A questionnaire was filled out by their parents. Results: The percentage of positive (≥2) CAP-RAST to JCP was 47.1% in children with allergic diseases and 19.9% in children without allergic diseases. In children with allergic diseases, the ratio had risen rapidly from 3 to 5 years old. In children without allergic diseases, the ratio of JCP sensitization has gradually increased from the infancy to adolescence. The youngest child who had been sensitized to JCP was 23-month-old boy with atopic dermatitis. The proportion of children who were born from January to march was significantly higher in JCP sensitized group than JCP non-sensitized group. The ratio of house dust mite and orchard grass pollen sensitization was higher in JCP sensitized group than those in JCP non-sensitized group. Conclusion: Large number of children acquire sensitization to JCP in their preschool age. We need to develop the way how to protect JCP sensitization in the early stage of life.

Journal

  • Japanese Journal of Allergology

    Japanese Journal of Allergology 55(10), 1312-1320, 2006

    Japanese Society of Allergology

References:  14

Cited by:  8

Codes

  • NII Article ID (NAID)
    110004860359
  • NII NACSIS-CAT ID (NCID)
    AN00012583
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0021-4884
  • NDL Article ID
    8563102
  • NDL Source Classification
    ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
  • NDL Call No.
    Z19-32
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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