ビタミンB群の過酸化脂質の生成における抗酸化作用と酸化促進作用について Antioxidant and Prooxidant Activities of B Group Vitamins in Lipid Peroxidation

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Abstract

ビタミンB群はこれまでいわゆる抗酸化ビタミンの範疇に分類されていなかったが, 最近一部の研究者がビタミンB群の抗酸化ビタミンの可能性を示唆する研究結果を発表している. そこで著者らはB群に属する6種類のビタミン(B<sub>1</sub>, B<sub>2</sub>, B<sub>6</sub>, B<sub>12</sub>, 葉酸, ニコチン酸)についてそれぞれのビタミンのリノール酸の過酸化脂質の生成に対する効果を塩化アルミニウム法によって分析した. その結果これらのビタミンの作用は大まかに三つのタイプに分かれ, 第一のタイプ(B<sub>1</sub>, B<sub>2</sub>, 葉酸, ニコチン酸)は過酸化脂質の生成の初期反応を促進し, その後の生成反応を抑制した. 第二のタイプのB<sub>12</sub>は初期反応に有意の効果を示さないが, その後の生成反応を抑制した. 第三のタイプのB<sub>6</sub>はすべての期間の生成反応を抑制した. 以上の結果より, ビタミンB群において過酸化脂質の生成に対してビタミンの種類や実験条件の違いによって抗酸化作用と酸化促進作用の両方の作用を示す可能性があることが示唆された.

The antioxidant and prooxidant activities of six B group vitamins against hydroperoxide generation in linoleic acid peroxidation were analyzed by the aluminum chrolide method. The B group vitamins were divided into three types by their antioxidant and prooxidant properties. The first type, including B<sub>1</sub>, B<sub>2</sub> vitamin, nicotinic acid and folic acid, showed prooxidant activities in the early phase (1 week) of the linoleic acid peroxidation at concentrations of 2.5 μM-2.5 mM, but caused relatively strong antioxidant activities in the later phase reaction (3 weeks) at the same concentrations. The second type, such as B<sub>12</sub> vitamin, did not cause significant effects in the early phases (1-2 weeks) of linoleic acid peroxidation, but exhibited significant antioxidant activities in the later phase reactions (3 weeks). The third type, such as B<sub>6</sub> vitamin, exhibited significant antioxidant activity in the early phase reaction and caused strong antioxidant effects in the later phase reaction (3 weeks). Generally, the antioxidant activities of B group vitamins in the later phases of lipid peroxidation was much stronger than those in the earlier phases. These experimental results suggest a possibility that B group vitamins have both antioxidant and prooxidant effects on lipid peroxidation under different experimental conditions.

Journal

  • Journal of UOEH

    Journal of UOEH 28(4), 359-368, 2006

    The University of Occupational and Environmental Health, Japan

Codes

  • NII Article ID (NAID)
    110004862612
  • NII NACSIS-CAT ID (NCID)
    AN0009832X
  • Text Lang
    ENG
  • ISSN
    0387-821X
  • NDL Article ID
    8597820
  • NDL Source Classification
    ZS7(科学技術--医学)
  • NDL Call No.
    Z19-1000
  • Data Source
    NDL  NII-ELS  J-STAGE 
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