Antiproliferative Constituents from Umbelliferae Plants(9)New Triterpenoid Glycosides from the Fruits of Bupleurum rotundifolium

• Fujioka Toshihiro

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Yoshida Keisuke

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Shibao Hiroko

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Nagao Tsuneatsu

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Yoshida Miyako

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Matsunaga Kazuhisa

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Takata Jiro

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Karube Yoshiharu

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Iwase Yukiko

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Okabe Hikaru

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Mihashi Kunihide

  Faculty of Pharmaceutical Sciences, Fukuoka University

書誌事項

タイトル別名

• Antiproliferative Constituents from Umbelliferae Plants. IX. New Triterpenoid Glycosides from the Fruits of Bupleurum rotundifolium

抄録

The MeOH extract of the fruits of Bupleurum rotundifolium showed inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. Bioactivity-guided fractionation of the MeOH extract led to the isolation of four new triglycosides of 13β,28-epoxy oleanane-type triterpenes, named rotundiosides O, Q, S and T; 12 new glycosides of oleanane-type triterpenes, named rotundiosides J—N, P, R, U—Y, and others; echinocystic acid 3-O-sulfate; and three known oleanane-type triterpene glycosides, rotundiosides A, F and G. The structures of the new isolates were determined based on chemical and spectroscopic evidence. The GI₅₀ of isolates against MK-1, HeLa and B16F10 cell lines are reported.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 54 (12), 1694-1704, 2006

  公益社団法人 日本薬学会

キーワード

• antiproliferative constituent
• <i>Bupleurum rotundifolium</i>
• Umbelliferae 13β,28-epoxy oleanane-type triterpene glycoside

詳細情報

• CRID: 1390282679148195968
• NII論文ID: 110004863642
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.54.1694
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 8548288
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8548288
• Web Site: http://www.jstage.jst.go.jp/article/cpb/54/12/54_12_1694/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可