Antiinflammatory and Antiallergic Activity of Bidens pilosa L. var. radiata SCHERFF

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Author(s)

Abstract

The suspension and the boiling water extract of dried powder from the aerial parts of <I>Bidens pilosa</I> L. var. <I>radiata</I> SCHERFF (<I>Tachiawayukisendangusa</I>: MMBP) on the Japanese island of Miyako have antiinflammatory and antiallergic properties in experimental diseases. Oral administration of MMBP suspension in carboxy-methyl-cellulose sodium solution inhibited the production of IgE 10 days after immunization with DNP-ascaris in mice. The extract inhibited histamine release from rat peritoneal mast cells induced by compound 48/80 or antigen-antibody reaction. Oral administration of the suspension inhibited dye exudation in rat skin induced by passive cutaneous anaphylaxis. Oral administration of the suspension inhibited dye exudation in rat skin induced by chemical mediators (histamine, substance P, and serotonin). These findings suggest that MMBP may be clinically useful in the prevention of type I allergic disease. <br>

Journal

  • Journal of Health Science

    Journal of Health Science 52(6), 711-717, 2006-12-01

    The Pharmaceutical Society of Japan

References:  25

Cited by:  5

Codes

  • NII Article ID (NAID)
    110004863676
  • NII NACSIS-CAT ID (NCID)
    AA11316464
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13449702
  • NDL Article ID
    8548933
  • NDL Source Classification
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL Call No.
    Z54-J464
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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