Mutation Spectrum Induced by Dihydropyrazines in Escherichia coli

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  • Takechi Shinji
    Faculty of Pharmaceutical Sciences, Sojo University
  • Yamaguchi Tadatoshi
    Faculty of Pharmaceutical Sciences, Sojo University
  • Nomura Hajime
    Department of Laboratory Medicine, Miyazaki Medical College
  • Minematsu Toshio
    Institute of Disease Control, Aisenkai Nichinan Hospital
  • Adachi Masaru
    Laboratory of Postharvest Biology and Technology, Faculty of Agriculture, University of Miyazaki
  • Kurata Hirofumi
    Laboratory of Genetic Engineering, Department of Biotechnology, Miyazaki Agricultural Experiment Station
  • Kurata Rie
    Laboratory of Upland Farming Research, National Agricultural Research Center for Kyushu Okinawa Region, Japan

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Dihydropyrazine (DHP), which induces mutagenesis in E. coli, was investigated. From analyzing mutations in the chromosomal rpoB gene, the mutation spectrum in uvrB strain revealed the different behavior on exposure to two DHP derivatives 3-hydro-2,2,5,6-tetramethylpyrazine (HTMP), and 2,3-dihydro-5,6-dimethylpyrazine (DHDMP). A higher level of DHP-induced mutation was observed, with base substitutions at G : C pairs predominant. HTMP and DHDMP increased the frequency of G : C to T : A transversions. HTMP increased the frequency of G : C to A : T transitions, than did DHDMP. These findings suggest that DHPs prefer to attack the G : C pair and that different DHP derivatives may prefer distinct mutagenic base pairs; and further, that nucleotide excision repair may be involved in the repair of DHP-induced mutations.

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