Effects of Pirenzepine on Dai-kenchu-to-Induced Elevation of the Plasma Neuropeptide Levels in Humans
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- Sato Yuhki
- Department of Clinical Pharmacy, Oita University Hospital
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- Inoue Shin
- Department of Clinical Pharmacy, Oita University Hospital
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- Katagiri Fumihiko
- Department of Clinical Pharmacy, Oita University Hospital
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- Itoh Hiroki
- Department of Clinical Pharmacy, Oita University Hospital
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- Takeyama Masaharu
- Department of Clinical Pharmacy, Oita University Hospital
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Dai-kenchu-to has been used for the treatment of abdominal obstructions, including bowel obstructions and a feeling of coldness in the abdomen. We reported that Dai-kenchu-to increases plasma neuropeptide [motilin, vasoactive intestinal polypeptide (VIP), serotonin, calcitonin gene-related peptide (CGRP), and substance P]-like immunoreactive substances (IS) levels and that its pharmacologic effects on the gastrointestine are due to changes in gastrointestinal mucosa-regulatory peptide levels. We examined the effects of the selective M1 muscarinic receptor antagonist pirenzepine on the elevation of Dai-kenchu-to-induced plasma neuropeptide (gastrin, motilin, somatostatin, VIP, CGRP, substance P)-IS levels in human volunteers and the area under the plasma neuropeptide concentration–time curve from 0 to 240 min (AUC0→240 min), which were calculated from the plasma neuropeptide concentration–time curves from each volunteers. Oral pretreatment with pirenzepine reduced the Dai-kenchu-to-induced elevation of plasma motilin and VIP-IS levels and AUC0→240 min. Combined treatment with Dai-kenchu-to and pirenzepine increased plasma somatostatin-IS levels and decreased plasma gastrin-IS levels and had no effects on plasma CGRP- and substance P-IS levels and AUC0→240 min compared with administration of Dai-kenchu-to alone. Dai-kenchu-to appeared to induce the release of motilin and VIP into plasma mainly through the activation of M1 muscarinic receptors, and pirenzepine may affect the pharmacologic action of Dai-kenchu-to by elevation of plasma motilin and VIP levels.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 29 (1), 166-171, 2006
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679601251200
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- NII論文ID
- 110005602105
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD28Xjsleit7g%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7756188
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- PubMed
- 16394532
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可