The Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus
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- Oh Myung Sook
- College of Oriental Medicine, Kyung Hee University
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- Park Chan
- College of Medicine, Kyung Hee University
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- Huh Youngbuhm
- College of Medicine, Kyung Hee University
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- Kim Hong-Yeoul
- Institute of Oriental Medicine, Kyung Hee University
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- Kim Hocheol
- College of Oriental Medicine, Kyung Hee University
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- Kim Hyung-Min
- College of Oriental Medicine, Kyung Hee University
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- Bae Hyunsu
- College of Oriental Medicine, Kyung Hee University
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- Ahn Duk Kyun
- Jaseng Research Institute of Bio-technology and Bioscience
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- Park Wan-Su
- College of Oriental Medicine, Kyung Hee University
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- Park Seong Kyu
- College of Oriental Medicine, Kyung Hee University
書誌事項
- タイトル別名
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- Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus
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抄録
BR003 is a multi-herbal formula that contains twelve medicinal herbs. We investigated the effects of oral administration of BR003 to Wistar rats on (a) learning and memory using a passive avoidance test and (b) cell proliferation in the dentate gyrus (DG) of the hippocampus using immunohistochemical analysis of 5-bromo-2-deoxyuridine (BrdU) expression. In the passive avoidance test, the retention time of the BR003-treated group was significantly longer than that of the control group (182.64±39.88 vs. 73.08±29.30 s, respectively; n=11; p<0.05). There were significantly more BrdU-immunoreactive cells in the DG in the BR003-treated group than in the control group (1281.07±151.16 vs. 818.01±132.98 cells per DG, respectively; n=11; p<0.05). These results suggest that the administration of BR003 not only improves learning and memory but also increases cell proliferation in the DG of the rat hippocampus.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 29 (4), 813-816, 2006
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390282679604293888
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- NII論文ID
- 110005602193
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7862074
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可