The Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus

書誌事項

タイトル別名
  • Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus

この論文をさがす

抄録

BR003 is a multi-herbal formula that contains twelve medicinal herbs. We investigated the effects of oral administration of BR003 to Wistar rats on (a) learning and memory using a passive avoidance test and (b) cell proliferation in the dentate gyrus (DG) of the hippocampus using immunohistochemical analysis of 5-bromo-2-deoxyuridine (BrdU) expression. In the passive avoidance test, the retention time of the BR003-treated group was significantly longer than that of the control group (182.64±39.88 vs. 73.08±29.30 s, respectively; n=11; p<0.05). There were significantly more BrdU-immunoreactive cells in the DG in the BR003-treated group than in the control group (1281.07±151.16 vs. 818.01±132.98 cells per DG, respectively; n=11; p<0.05). These results suggest that the administration of BR003 not only improves learning and memory but also increases cell proliferation in the DG of the rat hippocampus.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (55)*注記

もっと見る

詳細情報

問題の指摘

ページトップへ