MDR1 T-129C Polymorphism can be Predictive of Differentiation, and Thereby Prognosis of Colorectal Adenocarcinomas in Japanese

• Koyama Tatsuya

  Division of Clinical Pharmacokinetics, Department of General Therapeutics, Faculty of Medicine & Division of Biomedical Sciences, Kobe University Graduate School of Medicine

• Nakamura Tsutomu

  Department of Hospital Pharmacy, School of Medicine, Kobe University

• Komoto Chiho

  Department of Hospital Pharmacy, School of Medicine, Kobe University

• Sakaeda Toshiyuki

  Division of Clinical Pharmacokinetics, Department of General Therapeutics, Faculty of Medicine & Division of Biomedical Sciences, Kobe University Graduate School of Medicine Department of Hospital Pharmacy, School of Medicine, Kobe University

• Taniguchi Mayuko

  Division of Clinical Pharmacokinetics, Department of General Therapeutics, Faculty of Medicine & Division of Biomedical Sciences, Kobe University Graduate School of Medicine

• Okamura Noboru

  Department of Clinical Evaluation of Pharmacotherapy, Kobe University Graduate School of Medicine

• Tamura Takao

  Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine

• Aoyama Nobuo

  Department of Endoscopy, School of Medicine, Kobe University

• Kamigaki Takashi

  Division of Gastroenterological Surgery, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine

• Kuroda Yoshikazu

  Division of Gastroenterological Surgery, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine

• Kasuga Masato

  Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine

• Kadoyama Keiichi

  Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine

• Okumura Katsuhiko

  Division of Clinical Pharmacokinetics, Department of General Therapeutics, Faculty of Medicine & Division of Biomedical Sciences, Kobe University Graduate School of Medicine Department of Hospital Pharmacy, School of Medicine, Kobe University Department of Clinical Evaluation of Pharmacotherapy, Kobe University Graduate School of Medicine

抄録

The expression level of MDR1 mRNA was evaluated in colorectal adenocarcinomas and adjacent noncancerous colorectal tissues obtained from 21 Japanese patients. It was lower in the former than in the latter (p=0.012), suggesting its down-regulation as a consequence of malignant transformation of colorectal tissues, possibly with the suppression of differentiation. Relatively lower expression was suggested in moderately-differentiated colorectal adenocarcinomas than well-differentiated ones, but there was no statistical difference (p=0.111). MDR1 mRNA up-regulation was found in a colorectal adenocarcinoma cell line, HCT-15, after treatment with two typical differentiating agents, sodium butyrate and all-trans retinoic acid, suggesting its involvement in the cellular events, resulting in differentiation without malignant transformation. MDR1 T-129C, but not G2677A,T and C3435T, was associated with the lower expression of MDR1 mRNA both in colorectal adenocarcinomas (p=0.040) and adjacent noncancerous colorectal tissues (p=0.023), possibly being an useful invasive marker predicting poorly-differentiated colorectal adenocarcinomas and thereby the poor prognosis of the patients, especially when no extra biopsy samples will be obtained. Further investigations with relatively large number of patients should be undertaken to confirm these preliminary results.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 29 (7), 1449-1453, 2006

  公益社団法人 日本薬学会

キーワード

• colorectal adenocarcinoma
• MDR1
• expression
• differentiation
• genetic polymorphism

詳細情報

• CRID: 1390282679602668672
• NII論文ID: 110005602320
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.29.1449
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7960617
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7960617
• Web Site: http://www.jstage.jst.go.jp/article/bpb/29/7/29_7_1449/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007159777
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可