A Homeodomain-Zinc Finger Protein, ZFHX4, Is Expressed in Neuronal Differentiation Manner and Suppressed in Muscle Differentiation Manner
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- Hemmi Kazunori
- Department of Biochemistry, Showa Pharmaceutical University
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- Ma Dongping
- Department of Biochemistry and Molecular Biology, University of Calgary
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- Miura Yutaka
- Department of Bioregulation Research, Nagoya City University Medical School
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- Kawaguchi Makoto
- Second Department of Pathology, Faculty of Medicine, Toyama University
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- Sasahara Masakiyo
- Second Department of Pathology, Faculty of Medicine, Toyama University
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- Hashimoto-Tamaoki Tomoko
- Department of Genetics, Hyogo College of Medicine
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- Tamaoki Taiki
- Department of Biochemistry and Molecular Biology, University of Calgary
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- Sakata Nobuo
- Department of Biochemistry, Showa Pharmaceutical University
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- Tsuchiya Kayoko
- Department of Biochemistry, Showa Pharmaceutical University
書誌事項
- タイトル別名
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- Homeodomain Zinc Finger Protein ZFHX4 Is Expressed in Neuronal Differentiation Manner and Suppressed in Muscle Differentiation Manner
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Human ZFHX4 has recently been shown to be a candidate gene for congenital bilateral isolated ptosis. Here, we report molecular cloning of the human ZFHX4 cDNA and genomic organization of this gene. Human ZFHX4 is about 180 kb long, containing 12 exons that encodes a 3599-amino acid protein carrying four homeodomains and 22 zinc fingers. The 11th exon is 3.2 kb in length and encodes all the four homeodomains together with four of the 22 zinc fingers. ZFHX4 is 90% homologous to mouse Zfhx4, 52% to human ATBF1A and 24% to Drosophila ZFH-2. ZFHX4 was mapped to human chromosome 8q13.3-q21.11 by fluorescence in situ hybridization using BAC clone RP11-48D4 as a probe. RT-PCR analysis showed that ZFHX4 transcripts were expressed in adult human brain, liver and muscle. This, together with the finding that Zfhx4 was expressed transiently in differentiating P19 embryonal carcinoma cells and C2C12 myoblasts, suggests that ZFHX4/Zfhx4 is involved in neural and muscle differentiation.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 29 (9), 1830-1835, 2006
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390001204627567360
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- NII論文ID
- 110005602346
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 8026342
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
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