スポット尿中１１‐ｄｅｈｙｄｒｏ‐Ｔｈｒｏｍｂｏｘａｎｅ　Ｂ２レベルによるアスピリン耐性患者のスクリーニングは可能か？

• 吉田 久博

  明治薬科大学薬物体内動態学

• 高田 聡子

  明治薬科大学薬物体内動態学

書誌事項

タイトル別名

• Is it Possible to Screen Patients for Aspirin Resistance Using 11-dehydro-Thromboxane B2 Spot Urine Levels?

抄録

Thromboxane A₂ (TXA₂) is produced from arachidonic acid by cyclooxygenase-1 (COX-1) in thrombocytes and for the most part is converted to 11-dehydro-thromboxane B₂ (11dTXB₂), the final stable metabolite. Since daily excretion amounts of 11dTXB₂ in urine are well correlated with the degree of inhibition of COX-1 by aspirin, inhibition is evaluated by measuring 11dTXB₂ excretion and this is usually done through 24-hour urine collection. However, as this involves a lot of work, we examined the validity of using spot urine measurements for this purpose. The intra-day variation in urinary 11dTXB₂ levels was studied in five patients who had been taking low-dose aspirin for an extended period. Urinary concentrations of 11dTXB₂ were measured using a commercial enzyme immunoassay kit and the urinary excretion rate of 11dTXB₂ was expressed as the ratio of the concentration of 11dTXB₂ to that of creatinine. The results showed that there was no marked variation in intra-day urinary excretion rates and that the range of variation from 24-hour urine measurements was no more than about 15%. They therefore indicate that spot urine could be used in place 24-hour urine collection for measuring 11dTXB₂ levels.

収録刊行物

• 医療薬学

  医療薬学 32 (12), 1242-1247, 2006

  一般社団法人日本医療薬学会

キーワード

• Thromboxane A₂
• cyclooxygenase-1
• COX-1 inhibitor
• 11-dehydro-thromboxane B₂
• ELISA
• aspirin

詳細情報

• CRID: 1390282679751600256
• NII論文ID: 110005716595
• NII書誌ID: AA11527197
• DOI: 10.5649/jjphcs.32.1242
• ISSN: 18821499
• ISSN: 1346342X
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10558925
• Web Site: https://search.jamas.or.jp/link/ui/2007132896
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • NDL-Digital
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可