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- Cengiz Beyhan
- Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Oral Pathology and Medicine
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- Gunduz Mehmet
- Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Oral Pathology and Medicine
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- Gunduz Esra
- Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Oral Pathology and Medicine
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- Ouchida Mamoru
- Japan Institute for Advanced Dentistry
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- Shimizu Kenji
- Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Oral Pathology and Medicine
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- Inoue Tomio
- Japan Institute for Advanced Dentistry
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- Nagai Noriyuki
- Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Oral Pathology and Medicine
この論文をさがす
抄録
Tumor suppressor genes are defined as genetic elements whose loss or mutational inactivation allows cells to display one or more phenotypes of neoplastic growth. Frequent deletion in a chromosomal region suggests existence of a candidate tumor suppressor gene. We analyzed Ch2q21-37.3 region by using 17 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues. Loss of heterozygosity (LOH) was detected at least one location in 36 of 39 (92%) tumor tissues. High deletions were detected at microsatellite marker locations, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S164 (29%), D2S125 (71%) and D2S140 (39%). Three frequently deleted regions at 2q22, 2q35-36 and 2q37.3 were observed. Chromosomal 2q22-37.3 region is highly populated with genes. Several candidate tumor suppressor genes in this region including such as ING5, CASP8, CASP10, PPP1R7 and BOK are located. We are currently analyzing inactivation mutations and mRNA expressions in oral squaomus cell carcinomas.
収録刊行物
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- Journal of Hard Tissue Biology
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Journal of Hard Tissue Biology 14 (2), 227-228, 2005
硬組織再生生物学会
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詳細情報 詳細情報について
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- CRID
- 1390001204458824960
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- NII論文ID
- 110005853536
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- NII書誌ID
- AA11074332
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- ISSN
- 1880828X
- 13417649
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可