Gene Expression Profiling and Differentiation of Immortalized Human Mesenchymal Stem Cells

DOI 7 References
  • Mori Hiroki
    School of Pharmacy, Shujitsu University
  • Kato Junko
    School of Pharmacy, Shujitsu University
  • Matsuo Hirotami
    School of Pharmacy, Shujitsu University
  • Kobayashi Naoya
    Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University
  • Kosaka Yoshikazu
    Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University
  • Oka Takashi
    Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University
  • Tanaka Noriaki
    Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University
  • Nakanishi Tohru
    School of Pharmacy, Shujitsu University

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Abstract

Human bone marrow mesenchymal stem cells (hMSCs), tissue-derived stem cells, have the ability to differentiate into adipocytes, osteoblasts and chondrocytes, leading to attempt to apply these stem cells for regeneration of bone and cartilage. To address pluripotency of hMSCs, we analyzed gene expression profiles of several immortalized hMSCs with DNA chips that nearly covers the whole human genes. We isolated some factors that possibly relate to pluripotency of these hMSCs.

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