Sugihiratake Mushroom (Angel's Wing Mushroom)-Induced Cryptogenic Encephalopathy may Involve Vitamin D Analogues
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- Sasaki Hideki
- Nihon Waters K.K.
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- Akiyama Hiroshi
- National Institute of Health Sciences
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- Yoshida Yoshifumi
- Nihon Waters K.K.
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- Kondo Kazunari
- National Institute of Health Sciences
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- Amakura Yoshiaki
- National Institute of Health Sciences
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- Kasahara Yoshimasa
- Yamagata Prefectural Institute of Public Health
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- Maitani Tamio
- National Institute of Health Sciences
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In autumn 2004, many Japanese patients with renal failure developed cryptogenic encephalopathy by consuming sugihiratake mushroom, a Japanese delicacy. To elucidate the relationship between the cryptogenic cases and this mushroom, we conducted a multivariate analysis of metabolites in ‘Probably Toxic’ sugihiratake collected from the area of encephalopathy outbreaks, and ‘Probably Safe’ sugihiratake collected from unaffected areas using UPLC/ToF MS. The results indicate that the presence of milligram quantities of vitamin D-like compounds per 10 g of dried sugihiratake from the areas of encephalopathy outbreaks. Two hypotheses to induce the encephalopathy are proposed: the found metabolites are (1) vitamin D agonists, which induce acute and severe hypercalcemia and/or hyperammonemia and/or vitamin D toxicity, or (2) vitamin D antagonists, which induce acute and severe hypocalcemia.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 29 (12), 2514-2518, 2006
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204626478720
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- NII論文ID
- 110006148682
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 8548988
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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