Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats

• Oh Jin Kyung

  Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University

• Hyun Seung Ye

  Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University

• Oh Hye Rim

  Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University

• Jung Ji Wook

  Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University

• Park Chan

  Department of Anatomy, College of Medicine, Kyung Hee University

• Lee Sun-Young

  Graduate School of East-West Medical Science, Kyung Hee University

• Park Ji Ho

  Graduate School of East-West Medical Science, Kyung Hee University

• Kim Sun Yeou

  Graduate School of East-West Medical Science, Kyung Hee University

• Kim Ki Hoon

  Department of Forest Products, College of Forest Science, Kookmin University

• Kim Young Kyun

  Department of Forest Products, College of Forest Science, Kookmin University

• Ryu Jong Hoon

  Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University

抄録

The preventive effect of Anemarrhena asphodeloides BUNGE (Liliaceae), a traditional Chinese medicine, on ischemia-reperfusion-induced brain injury was evaluated in the rat brain. Ischemia was induced by intraluminal occlusion of the right middle cerebral artery for 2 h and reperfusion was continued for 22 h. Water extract of Anemarrhena asphodeloides (WEAA) was orally administered promptly prior to and 2 h after reperfusion. Total infarct volume and edema in the ipsilateral hemispheres of ischemia-reperfusion rats were significantly reduced by treatment with WEAA in a dose-dependent manner (p<0.05). The therapeutic time window of WEAA was 3 h in this ischemia-reperfusion rat model. WEAA also significantly inhibited increased neutrophil infiltration of ischemic brain tissue as estimated by myeloperoxidase (MPO) activity and immunohistochemical analysis. MPO-positive cells were markedly reduced by WEAA administration in striatal and cortical areas. These findings suggest that WEAA plays a crucial protective role in ischemia-induced brain injury, and suggest that WEAA could serve as a lead medicinal herb for the development of neuroprotective agents following transient focal ischemic brain injury.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 30 (1), 38-43, 2007

  公益社団法人 日本薬学会

キーワード

• <i>Anemarrhena asphodeloides</i>
• ischemia-reperfusion
• neutrophil
• myeloperoxidase (MPO)

詳細情報

• CRID: 1390282679603668992
• NII論文ID: 110006153263
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.30.38
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 8589952
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8589952
• Web Site: http://www.jstage.jst.go.jp/article/bpb/30/1/30_1_38/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007175121
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可