The Protective Effect of BRAND'S Essence of Chicken (BEC) on Energy Metabolic Disorder in Mice Loaded with Restraint Stress

  • Kurihara Hiroshi
    Institute of Traditional Chinese Medicine and Natural Products, Jinan University
  • Yao Xin-Sheng
    Institute of Traditional Chinese Medicine and Natural Products, Jinan University
  • Nagai Hajime
    BRAND'S Center for Health and Nutritional Sciences, Cerebos Pacific Ltd.
  • Tsuruoka Nobuo
    Institute for Health Care Science, Technological Development Center, Suntory Ltd.
  • Shibata Hiroshi
    Institute for Health Care Science, Technological Development Center, Suntory Ltd.
  • Kiso Yoshinobu
    Institute for Health Care Science, Technological Development Center, Suntory Ltd.
  • Fukami Harukazu
    Institute for Health Care Science, Technological Development Center, Suntory Ltd.

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  • Protective Effect of BRAND S Essence of Chicken BEC on Energy Metabolic Disorder in Mice Loaded with Restraint Stress

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We investigated the effects of BRAND'S Essence of Chicken (BEC) on the basic metabolism of plasma lipids in mice loaded with restraint stress. When a lipid emulsion was intravenously injected into mice, 20 hr restraint stress prolonged the elimination of plasma triglyceride (TG). The results indicated that lipid metabolism was definitely disrupted by stress, and that the use of TG as an energy source decreased. The plasma TG level was 320 ± 27 mg/dl 35 min after Intralipid® administration in restrained mice, while it was 253 ± 23 mg/dl in the restrained mice that were given 5 ml/kg of BEC. The improved plasma lipid metabolism was well explained by the finding that lipoprotein lipase in omental adipose tissue was remarkably improved by BEC. Our study shows that BEC improves metabolic dysfunction possibly by utilizing plasma lipids as energy sources and elevating lipoprotein lipase activity reduced by stress. The anti-stress effect of BEC may partly be related to improved plasma lipid metabolism for energy utilization. <br>

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