Genotoxicity of Microbial Volatile Organic Compounds

• Nakajima Daisuke

  Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies

• Ishii Ruri

  Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies

• Kageyama Shiho

  Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies

• Onji Yoshiki

  Air Environment Division, Nara Prefectural Institute for Hygiene and Environment

• Mineki Shigeru

  Faculty of Science and Technology, Tokyo University of Science

• Morooka Nobuhisa

  Faculty of Home Economics, Koriyama Women's University

• Takatori Kosuke

  Division of Microbiology, National Institute of Health Sciences

• Goto Sumio

  Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies

Abstract

Luminescent and light absorption umu tests were used to investigate the genotoxicity of microbial volatile organic compounds (MVOCs), which have been reported to occur in conjunction with the growth of filamentous fungi. Investigation of 20 types of MVOC samples confirmed the SOS-inducing activity of 1-octen-3-ol, 2-methyl-1-propanol, 2-heptanone, 3-octanol, 1-pentanol, 1-butanol, 2-methyl-1-butanol, 3-methyl-1-butanol, 3-methyl-2-butanol, 3-octanone, 2-hexanone, 2-butanone, 3-methyl-2-butanone, 2-pentanol, ethyl isobutyrate, and terpinen-4-ol. Of these materials, 3-methyl-2-butanone and 3-methyl-2-butanol, which were positive in both the luminescent and light absorption umu tests, were clearly shown also to be mutagenic based on the results of the Ames test. Each of these 20 MVOCs is known to be produced by microorganisms commonly detected in indoor environments, and long-term exposure could be a health hazard. <br>

Journal

• Journal of Health Science

  Journal of Health Science 52 (2), 148-153, 2006

  The Pharmaceutical Society of Japan

Keywords

• microbial volatile organic compound
• fungi
• <I>umu</I> test
• Ames test
• mutagenicity

Details

• CRID: 1390001204499466624
• NII Article ID: 110006163230
• NII Book ID: AA11316464
• DOI: 10.1248/jhs.52.148
• ISSN: 13475207
• ISSN: 13449702
• NDL BIB ID: 7865955
• Web Site: http://id.ndl.go.jp/bib/7865955
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7865955
• Web Site: http://www.jstage.jst.go.jp/article/jhs/52/2/52_2_148/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007157250
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed