Bone formation in titanium porous scaffold with immobilization of BMP-2

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  • MATSUZAKA Kenichi
    Department of Clinical Pathophysiology and Oral Health Science Center, Tokyo Dental College
  • YOSHINARI Masao
    Department of Dental Materials Science and Oral Health Science Center, Tokyo Dental College
  • KOKUBU Eitoyo
    Department of Clinical Pathophysiology and Oral Health Science Center, Tokyo Dental College
  • SHIMONO Masaki
    Department of Pathology and Oral Health Science Center, Tokyo Dental College
  • YAMADA Yasuo
    Materials Research Institute for Sustainable Development, National Institute of Advanced Industrial Science and Technology (Chubu)
  • MABUCHI Mamoru
    Department of Energy Science and Technology, Graduate School of Energy Science, Kyoto University
  • INOUE Takashi
    Department of Clinical Pathophysiology and Oral Health Science Center, Tokyo Dental College

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Abstract

Objectives. Bone defects make up a significant clinical problem. The purpose of the present study was to evaluate the osteogenic tissue behavior in a titanium (Ti) porous scaffold with immobilization of bone morphogenetic protein (BMP) -2 in vivo.<BR>Methods. Ti scaffold (pore size: 200-500 μm) with or without BMP-2 immobilization was implanted into a created defect of a rat femur.<BR>Results. One week after implantation, only bone marrow cells were present around the scaffold without BMP, but new bone formation could be observed around the scaffold with BMP. Two weeks after implantation, new bone tissue had formed around the scaffold with and without BMP-2 immobilization.<BR>Conclusions. Ti porous scaffold with BMP-2 immobilization can manufacture new bone tissue at an early stage, and can be a beneficial in the repair of bone defects.<BR>

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