Local application of simvastatin to rat incisor socket : Carrier-dependent effect on bone augmentation

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Author(s)

    • SATO D
    • Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University
    • NISHIMURA Kenichi
    • Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University
    • ISHIOKA Tatsunari
    • Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University
    • KONDO Hisatomo
    • Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University
    • KURODA Shinji
    • Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University
    • KASUGAI Shohei
    • Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University

Abstract

It has been reported that simvastatin, which is a cholesterol synthesis inhibitor and a therapeutic drug for hypercholesteremia, stimulates bone morphogenetic protein 2 expression in osteoblasts, suggesting potentiality of simvastatin in local bone augmentation. We prepared bovine atelo-collagen or calcium sulfate containing simvastatin and applied these materials to the rat lower incisor sockets. After 4 weeks, the bone of the extracted site was examined radiographically and histologically. Calcium sulfate containing simvastatin remarkably increased the thickness of the alveolar bone. This effect was not observed when simvastatin alone was applied or when atelo-collagen was used as a drug carrier. Although further studies are required, the present results indicate that simvastatin augments bone around tooth socket, which is carrier-dependent.

Journal

  • Journal of Oral Tissue Engineering

    Journal of Oral Tissue Engineering 2(2), 81-85, 2005

    Japanese Association of Regenerative Dentistry

Cited by:  3

Codes

  • NII Article ID (NAID)
    110006164164
  • NII NACSIS-CAT ID (NCID)
    AA1195240X
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13489623
  • Data Source
    CJPref  NII-ELS 
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