シーフードによる職業性の接触蕁麻疹と口腔アレルギー症候群の1例  [in Japanese] A CASE OF OCCUPATIONAL CONTACT URTICARIA AND ORAL ALLERGY SYNDROME DUE TO SEAFOOD  [in Japanese]

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Author(s)

    • 山口 絢子 Yamaguchi Junko
    • 横浜市立大学大学院医学研究科環境免疫病態皮膚科学 Department of Dermatology, School of Medicine, Yokohama City University
    • 猪又 直子 Inomata Naoko
    • 横浜市立大学大学院医学研究科環境免疫病態皮膚科学 Department of Dermatology, School of Medicine, Yokohama City University
    • 塩見 一雄 Shiomi Kazuo
    • 東京海洋大学海洋科学部海洋食品科学科 Department of Food Science and Technology, Tokyo University of Fisheries
    • 池澤 善郎 Ikezawa Zenro
    • 横浜市立大学大学院医学研究科環境免疫病態皮膚科学 Department of Dermatology, School of Medicine, Yokohama City University

Abstract

20歳女性.乳児期よりアトピー性皮膚炎.幼少時より生魚を接触した際に〓痒を認めたが経口摂取は可能であった.2年前に回転寿司屋でアルバイトを開始してから,数滴の魚液に接触しただけで手の腫脹が出現した.1年前からはシタビラメやサンマ,アジ,サケ,ホッケ,ブリを加熱調理して摂取時に口唇〓痒や腫脹,アナゴ摂取時に喉頭閉塞感や嗄声,エビやカニを摂取時に口唇腫脹,アワビに似た貝を摂取時に喘鳴や嗄声,呼吸困難,全身性蕁麻疹が出現した.特異IgE抗体やプリックテストでは硬骨魚綱,甲殻鋼,軟体動物等多種で陽性.焼シタビラメによる口含み試験では口唇違和感が出現し,経口負荷試験では口唇腫脹や喉頭閉塞感,嚥下困難感,腹痛が出現した.パルブアルブミンとコラーゲンに対する血清特異IgE抗体は,ELISA法にて検出.以上よりシーフードによる職業性の接触蕁麻疹と口腔アレルギー症候群と診断した.

A 20-year-old woman was referred for evaluation after about 2 years of recurrent episodes of localized urticaria during handling of several kinds of raw fish in a sushi shop, where she had worked part-time for 2 years. She had also experienced allergic symptoms such as itching and swelling of her lips, generalized urticaria, laryngeal tightness, stridor and dyspnea immediately after ingestion of raw and cooked seafood, including sole, horse mackerel, sea eel and shellfish, over the previous 1 year before referral. Skin prick tests and blood test for specific IgE antibodies were positive for many kinds of seafood, including sole, horse mackerel, sea eel, eel, crab, and abalone, which belonged to different taxonomic phyla, including Chordata, Arthropoda, and Mollusca. A challenge with a piece of broiled sole induced swelling of the lips, obstruction of the larynx, difficulty with deglutition, and abdominal pain. In addition, serum-specific IgE antibodies to two major fish allergens, parvalbumin and collagen, were detected by ELISA, suggesting that allergic symptoms could be induced by many kinds of seafood in the present patient She was therefore diagnosed with occupational contact urticaria and oral allergy syndrome due to seafood. At the time of this report, the present patient had been followed for one year and no reactions have occurred since she started to avoid the causative types of seafood.

Journal

  • Japanese Journal of Allergology

    Japanese Journal of Allergology 56(1), 49-53, 2007

    Japanese Society of Allergology

References:  12

Codes

  • NII Article ID (NAID)
    110006164371
  • NII NACSIS-CAT ID (NCID)
    AN00012583
  • Text Lang
    JPN
  • Article Type
    NOT
  • ISSN
    0021-4884
  • NDL Article ID
    8671057
  • NDL Source Classification
    ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
  • NDL Call No.
    Z19-32
  • Data Source
    CJP  NDL  NII-ELS  J-STAGE 
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