950ppmFフッ化ナトリウムおよびモノフルオロリン酸ナトリウムのエナメル質耐酸性に及ぼす影響  [in Japanese] Differences in Effects of Sodium Fluoride and Sodium Monofluorophosphate on Acid Resistance of Enamel  [in Japanese]

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Author(s)

    • 加藤 一夫 KATO Kazuo
    • 愛知学院大学歯学部口腔衛生学講座 Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University
    • 中垣 晴男 NAKAGAKI Haruo
    • 愛知学院大学歯学部口腔衛生学講座 Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University

Abstract

フッ化ナトリウム(NaF)とモノフルオロリン酸ナトリウム(MFP)は,ともに歯磨剤に配合されるう蝕予防の有効成分として最も広く用いられている.本研究の目的は,日常のセルフケアにおいてフッ化物配合歯磨剤の使用を考慮し設定した条件下で,エナメル質耐酸性に及ぼすNaFとMFPの作用の違いを明らかにすることであった.950ppmFに調整したNaFまたはMFPの水溶液で1日2回3分間,エナメル質を処理し,それ以外はpH4.5の脱灰液に浸漬した.この操作を22日間行った後,試料のミネラル量の変化(ΔZおよびLd)をX線マイクロラジオグラフ(XMR)により定量した.その結果,NaF処理群は,MFP処理群より有意に高い耐酸性を示した(ΔZ: NaF<MFP, Ld: NaF<MFP). 22日間のフッ化物処理による耐酸性層の構造を明らかにするため,pH4.0の脱灰液で6日間処理したところ,NaFとMFPのXMR像には大きな違いがあった.NaF処理群は,表面付近に限定して耐酸性を示す100μm程度の層が得られた.一方,MFP処理群は表層付近の耐酸性がNaFに比べ劣るものの,経時的にエナメル質内部に深くまで浸透し,300μm程度の耐酸性を形成した.したがって,今回の条件における耐酸性付与に関するNaFとMFPの作用は互いに対照的であり,その特性に合わせた応用が望まれる.

Sodium fluoride (NaF) and Sodium monofluorophosphate (MFP) are the most common anticaries ingredients used in fluoride dentifrices. The purpose of this study was to investigate the differences in effects of NaF and MFP on acid resistance of enamel. In this study, we employed conditions of fluoride treatment which simulated the daily use of fluoride dentifrices. The treatment of enamel specimens was carried out in solution of 950 ppmF NaF or MFP (2 times/day, 3 min/time, for 22 days). Following fluoride treatments, specimens were immersed in demineralizing solution (pH 4.5). The changes in lesion mineral contents, ΔZ, and the lesion depth (Ld) were assessed by quantitative microradiography. Enamel specimens treated with NaF showed significantly higher acid resistance than with MFP treatment (ΔZ: NaF<MFP, Ld: NaF<MFP). After 22-day fluoride treatment, specimens were demineralized (pH 4.0) for 6 days to investigate the structure of the acid-resistant layer. Microradiography revealed large differences in acid resistance between NaF and MFP. NaF-treated enamel showed acid resistant at only a superficial area. However, MFP-treated enamel had a thick and deep acid-resistant layer. Therefore, NaF could not penetrate into the enamel, while MFP penetrated deeper. The results showed that NaF and MFP made an interesting contrast concerning the investment of acid resistance under acidic conditions.

Journal

  • JOURNAL OF DENTAL HEALTH

    JOURNAL OF DENTAL HEALTH 57(1), 13-21, 2007

    Japanese Society for Oral Health

References:  21

Cited by:  6

Codes

  • NII Article ID (NAID)
    110006164443
  • NII NACSIS-CAT ID (NCID)
    AN00081407
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0023-2831
  • NDL Article ID
    8675503
  • NDL Source Classification
    ZS44(科学技術--医学--歯科学・口腔外科学)
  • NDL Call No.
    Z19-144
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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