510 血管狭窄部における血栓形成の粒子法シミュレーション(J01-2 計算生体力学におけるマルチスケール・マルチフィジックス問題(2),J01 計算生体力学におけるマルチスケール・マルチフィジックス問題)

• 鎌田 裕基

  東北大

• 坪田 健一

  東北大

• 和田 成生

  東北大

• 山口 隆美

  東北大

書誌事項

タイトル別名

• 510 A particle method simulation of the thrombogenesis in stenosed blood vessel

抄録

A two-dimensional particle method simulation of blood flow was carried out to investigate effects of stenosis on primary thrombogenesis due to platelet aggregation. In the employed particle method, the blood region was discritized by moving particles that have the characteristics of plasma and platelets. Two geometrically different models were constructed for straight and stenosed vessels. As a result, it was shown that platelets adhered to cover the whole area of the injured wall in the straight model. In the case of the stenosed model, platelets adhered on the downstream side of the injured wall and not on that of the upstream side. This was caused by the disturbance of the blood flow due to the geometrical nonuniformity of stenosis, leading to local growth of the thrombus. These results suggest that thrombogensis is influenced by the blood flow pattern depending on the vessel geometry.

収録刊行物

• 年次大会講演論文集

  年次大会講演論文集 2005.6 (0), 19-20, 2005

  一般社団法人 日本機械学会

キーワード

• Particle Method
• Platelet
• Thrombogenesis
• Thrombus
• Moving Particle Semi-implicit (MPS) Method
• Blood flow
• Computational Fluid Dynamics (CFD)

詳細情報

• CRID: 1390282681038347776
• NII論文ID: 110006191070
• DOI: 10.1299/jsmemecjo.2005.6.0_19
• ISSN: 24331325
• Web Site: https://www.jstage.jst.go.jp/article/jsmemecjo/2005.6/0/2005.6_19/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可