1254 力学刺激に対する単離骨細胞の応答観察(J03-1 細胞の構造と流れのメカニクス(1),J03 細胞の構造と流れのメカニクス)

• 田中 基嗣

  京都大・工

• 青沼 有紀

  神戸大・院

• 安達 泰治

  京都大・工

• 上岡 寛

  岡山大・医歯薬

• 山本 照子

  岡山大・医歯薬

• 北條 正樹

  京都大・工

書誌事項

タイトル別名

• 1254 Response of Isolated Osteocyte to Mechanical Stimulus

抄録

Osteocyte network system embedded in bone matrix is considered as one of the important elements in the mechanosensory mechanism. This study observed the response of an isolated osteocyte to mechanical stimulus, as the first step to clarify the complex mechanisms of mechanosensing and signal transduction of the osteocyte network in living tissue matrix. Change in the intracellular Ca^<2+> concentration induced by mechanical stimulus to the osteocyte cell body was observed, and the sensitivity to the stimulus was compared with that of the osteoblast. In addition, the role of cytoskeletal actin filaments in the mechanosensory mechanism was discussed in terms of its localized distribution in the cell body and processes through the comparison with the osteoblasts.

収録刊行物

• 年次大会講演論文集

  年次大会講演論文集 2005.6 (0), 119-120, 2005

  一般社団法人 日本機械学会

キーワード

• Osteocyte
• Mechanosensory mechanism
• Mechanical stimulus
• Actin filament
• Cell biomechanics

詳細情報

• CRID: 1390001206061947392
• NII論文ID: 110006191120
• DOI: 10.1299/jsmemecjo.2005.6.0_119
• ISSN: 24331325
• Web Site: https://www.jstage.jst.go.jp/article/jsmemecjo/2005.6/0/2005.6_119/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可