Dimerization of Parallel G-Quadruplex DNA Formed from TTAGGG and Interaction between G-Quadruplex DNA and Porphyrin Derivatives

• YAMAMOTO Yasuhiko

  Department of Chemistry, University of Tsukuba

• MITA Hajime

  Department of Chemistry, University of Tsukuba

• OHYAMA Takako

  Department of Chemistry, University of Tsukuba

Bibliographic Information

Other Title

• 四重鎖ＤＮＡのダイナミクスとポルフィリン誘導体との相互作用
• 4ジュウサ DNA ノ ダイナミクス ト ポルフィリン ユウドウタイ ト ノ ソウゴ サヨウ

Abstract

A G-quadruplex DNA is composed of stacked G-quartets, each of which involves the planar association of four guanine bases. The size and planarity of a G-quartet are well-suited for interacting with a porphyrin ring through <symbol>π</symbol>-<symbol>π</symbol> stacking. We have demonstrated the formation of a stable coordination complex between heme, the iron (III)-protoporphyrin IX complex, and a parallel G-quadruplex DNA assembled from a single repeat sequence of the human telomere, TTAGGG. The heme-DNA complex was found to be remarkably similar, in various spectroscopic and functional properties, to hemoprotein such as myoglobin.<br>

Journal

• Seibutsu Butsuri

  Seibutsu Butsuri 47 (1), 023-028, 2007

  The Biophysical Society of Japan General Incorporated Association

Keywords

• coordination complex
• G-quartet
• heme
• molecular recognition
• porphyrin derivative
• quadruplex DNA

Details

• CRID: 1390282681511633408
• NII Article ID: 110006201585
• NII Book ID: AN00129693
• DOI: 10.2142/biophys.47.023
• ISSN: 13474219
• ISSN: 05824052
• NDL BIB ID: 8679839
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8679839
• Web Site: http://www.jstage.jst.go.jp/article/biophys/47/1/47_1_023/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed