Effects of single administration of Rokumi-gan (TJ-87) on serum amino acid concentration of 6 healthy Japanese male volunteers
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- Takahashi Hideo
- Department of Internal Medicine, The Komatsushima Hospital
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- Nakao Reiko
- Department of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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- Hirasaka Katsuya
- Department of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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- Kishi Kyoichi
- Department of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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- Nikawa Takeshi
- Department of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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Abstract
Rokumi-gan (TJ-87) has beneficial effects on renal diseases, including pollakisuria, dysuria and edema. We previously reported that its long-term administration clinically improved serum protein concentration and edema in renal failure. In this study, we focused on amino acid/protein contents in Rokumi-gan as one of its effectors. Commercially prepared Rokumi-gan contained arginine, aspartate and glutamate at the high levels, alanine, phenylalanine and serine at the moderate levels, and glycine, histidine, isoleucine, leucine, lysine and valine at the low levels. To examine effects of Rokumi-gan on serum amino acid concentrations, 6 healthy Japanese volunteers were treated with commercially prepared Rokumi-gan, an amino acid mixture, and lactose. In subjects treated with an amino acid mixture containing similar amounts of amino acids in Rokumi-gan (10 g), or lactose, serum amounts of many amino acids, except for arginine, gradually and significantly decreased until 6 hr after their treatments. In contrast, a single treatment with Rokumi-gan (10 g) increased serum levels of several amino acids, alanine, arginine, glutamate, glycine and serine. Serum concentrations of almost of all tested amino acids showed the peak value 1-2 hr after administration, and they were sustained at the basal level even 6 hr after the treatment. Our present results suggest that Rokumi-gan may be a beneficial amino acid supplier, because it could sustain serum amino acid concentration at the higher level than an amino acid mixture supplement. J. Med. Invest. 54: 91-98, February, 2007
Journal
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- The Journal of Medical Investigation
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The Journal of Medical Investigation 54 (1,2), 91-98, 2007
The University of Tokushima Faculty of Medicine
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Details 詳細情報について
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- CRID
- 1390001204243089280
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- NII Article ID
- 110006215205
- 130004465136
- 120006470118
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- NII Book ID
- AA11166929
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- ISSN
- 13496867
- 13431420
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed