Bioactive Saponins and Glycosides(27)Structures or New Cucurbitane-Type Triterpene Glycosides and Antiallergic Constituents from Citrullus colocynthis

• Yoshikawa Masayuki

  Kyoto Pharmaceutical University

• Morikawa Toshio

  Kyoto Pharmaceutical University Pharmaceutical Research and Technology Institute, Kinki University

• Kobayashi Hisanori

  Kyoto Pharmaceutical University

• Nakamura Akihiko

  Kyoto Pharmaceutical University

• Matsuhira Koudai

  Kyoto Pharmaceutical University

• Nakamura Seikou

  Kyoto Pharmaceutical University

• Matsuda Hisashi

  Kyoto Pharmaceutical University

書誌事項

タイトル別名

• Bioactive Saponins and Glycosides. XXVII. Structures of New Cucurbitane-Type Triterpene Glycosides and Antiallergic Constituents from Citrullus colocynthis

抄録

The methanolic extract from the fruit of Citrullus colocynthis showed an inhibitory effect on ear passive cutaneous anaphylaxis reactions as a type I allergic model in mice. From the methanolic extract, two new cucurbitane-type triterpene glycosides, colocynthosides A and B, were isolated together with 17 known constituents. The structures of colocynthosides A and B were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal cucurbitane-type triterpene glycoside, cucurbitacin E 2-O-β-D-glucopyranoside, and its aglycon, cucurbitacin E, exhibited the antiallergic activity at a dose of 100 and 1.25 mg/kg, p.o., respectively.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 55 (3), 428-434, 2007

  公益社団法人 日本薬学会

キーワード

• <i>Citrullus colocynthis</i>
• colocynthoside
• colocynthol
• cucurbitacin E 2-<i>O</i>-β-<small>D</small>-glucopyranoside
• cucurbitane-type triterpene
• antiallergic activity

詳細情報

• CRID: 1390282679145860992
• NII論文ID: 110006225094
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.55.428
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 8658293
• Web Site: http://id.ndl.go.jp/bib/8658293
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8658293
• Web Site: http://www.jstage.jst.go.jp/article/cpb/55/3/55_3_428/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007203849
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可