治療抵抗性うつ病に奏効する薬剤の創薬を目指して</br>—電気けいれん療法の有用性と脳由来神経栄養因子（BDNF）の関与—

• 李 炳錦

  愛媛大学大学院医学系研究科脳・神経病態制御医学臨床薬理薬剤学

• 末丸 克矢

  愛媛大学大学院医学系研究科脳・神経病態制御医学臨床薬理薬剤学 愛媛大学医学部附属病院薬剤部

• 北村 佳久

  岡山大学医学部歯学部附属病院薬剤部

• 崔 然吉

  愛媛大学大学院医学系研究科脳・神経病態制御医学臨床薬理薬剤学

• 五味田 裕

  岡山大学医学部歯学部附属病院薬剤部

• 荒木 博陽

  愛媛大学大学院医学系研究科脳・神経病態制御医学臨床薬理薬剤学 愛媛大学医学部附属病院薬剤部

書誌事項

タイトル別名

• Strategy to Develop a New Drug for Treatment-resistant Depression</br>—Role of Electroconvulsive Stimuli and BDNF—
• 治療抵抗性うつ病に奏効する薬剤の創薬を目指して--電気けいれん療法の有用性と脳由来神経栄養因子(BDNF)の関与
• チリョウ テイコウセイ ウツビョウ ニ ソウコウスル ヤクザイ ノ ソウヤク オ メザシテ デンキ ケイレン リョウホウ ノ ユウヨウセイ ト ノウ ユライ シンケイ エイヨウ インシ BDNF ノ カンヨ
• Strategy to Develop a New Drug for Treatment-resistant Depression</br>&mdash;Role of Electroconvulsive Stimuli and BDNF&mdash;
• Strategy to develop a new drug for treatment-resistant depression-role of electroconvulsive stimuli and BDNF

抄録

  In recent years, depression studies have focused on morphological changes associated with depression. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that plays an important role in the morphological changes associated with depression and the mechanisms of antidepressants. On the other hand, hyperfunction of the hypothalamic-pituitary-adrenal axis has been link to pathophysiology of depression. In our previous studies, ACTH-treated rats served as a valuable animal model of tricyclic antidepressant-resistant depressive conditions. However, few neuroanatomic studies have been done. In the present study, we investigated mechanisms underling ACTH-treated rat serving an imipramine treatment-resistant depression model using c-Fos as a marker. The c-Fos immunohistochemical study indicated that the medial prefrontal cortex is an action site of imipramine in ACTH-treated rats. Electroconvulsive therapy is considered an effective treatment for treatment-resistant depression. However, the mechanisms causing treatment-resistant depressive conditions are unknown. We investigated the effect of repeated electrical convulsive shock (ECS)-treatment using the forced swim test, a screening method for antidepressant-like activity, and hippocampal BDNF protein levels in ACTH-treated rats. Findings showed that repeated ECS treatment decreased the immobility time during forced swim test. Furthermore, the ECS treatment also markedly increased the hippocampal BDNF levels in the rat tricyclic antidepressant-resistant depression model. In addition, the repeated ECS treatment showed long-lasting effects on forced swim test and increased of hippocampal BDNF levels in normal rats. These findings suggest that BDNF plays a key role in the antidepressant-like effect of ECS and that increased BDNF may be involved in promoting the long-lasting effect.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 127 (4), 735-742, 2007

  公益社団法人 日本薬学会

キーワード

• treatment-resistant depression
• antidepressant
• electrical convulsive shock
• brain-derived neurotrophic factor (BDNF)
• hypothalamic-pituitary-adrenal (HPA) axis

詳細情報

• CRID: 1390001206129344896
• NII論文ID: 110006242880
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.127.735
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 8766792
• Web Site: http://id.ndl.go.jp/bib/8766792
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8766792
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/127/4/127_4_735/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007221773
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可