ブタ舌動脈血管平滑筋に対する炎症性ケミカルメディエータの影響  [in Japanese] Effects of inflammatory chemical mediators on porcine lingual arterial smooth muscle  [in Japanese]

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Author(s)

    • 西 健 Nishi Takeshi
    • 岩手医科大学歯学部歯科麻酔学講座 Department of Dental Anesthesiology, School of Dentistry, Iwate Medical University
    • 佐藤 健一 Satoh Ken-ichi
    • 岩手医科大学歯学部歯科麻酔学講座 Department of Oral Pathology, School of Dentistry, Iwate Medical University

Abstract

To elucidate the effects of various chemical mediators, which are considered to appear in inflammation, on vascular smooth muscle, annular specimens of porcine lingual arterial smooth muscle were prepared, and divided into specimens denuded or undenuded of vascular endothelium. These specimens were attached to the thermostat incubator of an intracellular calcium ion concentration measurement unit, stimulated with 40 mM KCl, noradrenalin (NA), or U46619, followed by administration of acetylcholine (ACh) or bradykinin (BK), and the isometric contractile tension generated and fluorescence intensity ratio were simultaneously measured ; the following conclusions were drawn. 1. The inhibition by ACh or BK of NA-, high KCl-, or U46619-induced contraction was dependent on the presence of vascular endothelium, suggesting the involvement of a decreased [Ca^<2+>]_i concentration in the contraction inhibition. 2. It was suggested that the inhibition of high KCl-induced contraction by ACh or BK was weaker than that of receptor stimulation-induced contraction. 3. The administration of BK showed biphasic changes in U46619-induced contractile tension and [Ca^<2+>]_i.

Journal

  • Dental Journal of Iwate Medical University

    Dental Journal of Iwate Medical University 32(1), 25-34, 2007

    The Dental Society of Iwate Medical University

References:  18

Cited by:  1

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