2,3,7,8-tetrachlorodibenzo-p-doxin(TCDD)雄親直接曝露は次世代性比へ影響を与えるか-

DOI 日本農学文献記事索引 Web Site Web Site PubMed 被引用文献1件 参考文献39件
  • ISHIHARA Kana
    Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
  • WARITA Katsuhiko
    Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
  • TANIDA Takashi
    Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
  • SUGAWARA Teruo
    Department of Molecular Biochemistry, Graduate School of Medicine, Hokkaido University
  • KITAGAWA Hiroshi
    Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
  • HOSHI Nobuhiko
    Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University

書誌事項

タイトル別名
  • Dose Paternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) affect the Sex Ratio of Offspring?
  • Anatomy: Does paternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affect the sex ratio of offspring?
  • Does paternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affect the sex ratio of offspring?

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抄録

In 1976, men who were exposed to the highest concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) after an explosion at a chemical plant near Seveso, Italy, produced more girls than boys. However, few studies have examined the possibility that the exposure of laboratory animals to TCDD, especially that of males, could lead to a lower male/female sex ratio. The aim of this study was to investigate whether direct paternal exposure to TCDD affects the sex ratio of offspring using a relatively large-scale experimental design. Male ICR mice (n=120) were randomly assigned to three, one of which served as a vehicle control, the other two were administered TCDD orally with an initial loading dose of 2 or 2,000 ng TCDD/kg, followed by a weekly maintenance dose of 0.4 (T2/0.4 group) or 400 (T2000/400 group) ng/kg prior to mating. The major organs of each mouse were weighed and histopathologically and immunohistologically investigated, and the sex ratio of offspring [males/(males + females) × 100] was calculated in each dam. There were no significant effects on organ weights, or on the structure of the testis and epididymis between the control and TCDD-exposed males, but TCDD administration produced a significantly lower proportion of male offspring from T2000/400-exposed sires despite no alteration in litter size (Control: 53.1 ± 1.7; T2/0.4: 48.8 ± 2.5; T2000/400: 46.2 ± 2.1). In addition, we further divided the T2000/400 group into 3 subgroups based on the proportion of CYP1A1-immunoreactive areas in the liver; there was a significant correlation between sex ratio and CYP1A1 immunoreactivity. Thus, the present study confirms that direct paternal exposure to TCDD might be associated with an alteration in the sex ratio of offspring. Possible mechanisms through which TCDD might decrease the fertility potential of Y-bearing gametes before conception are discussed.<br>

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