Morphology, Function, and Differentiation of Bone Cells

• Nakamura Hiroaki

  Department of Oral Histology, Matsumoto Dental University

Abstract

Bone plays a pivotal role in storing calcium and phosphate in vertebrates. This tissue is maintained by the balance of bone formation and bone resorption. Osteoblast-lineage cells, consisting of osteoblasts, osteocytes and bone lining cells, are engaged in bone formation. Bone resorption is mediated by osteoclasts. Recent research revealed that receptor activator of NF-κB (RANK)-RANK ligand (RANKL) mechanism is essential for the differentiating and activating osteoclasts. Osteoblast-lineage cells regulate bone resorption via the expression of RANKL and osteoprotegerin (OPG), a decoy receptor for RANKL. Additionally, osteoblast-lineage cells participate in degradation of bone matrix by secreting MMP-13. Thus, bone remodeling is achieved by the harmonized orchestration of osteoblast-lineage cells and osteoclast-lineage cells.

Journal

• Journal of Hard Tissue Biology

  Journal of Hard Tissue Biology 16 (1), 15-22, 2007

  THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY

Keywords

• Bone
• Cell-cell interaction
• Osteoblasts
• Osteoclasts

Details

• CRID: 1390282679435015168
• NII Article ID: 110006250202
• NII Book ID: AA11074332
• DOI: 10.2485/jhtb.16.15
• ISSN: 1880828X
• ISSN: 13417649
• NDL BIB ID: 8816248
• Web Site: https://mdu.repo.nii.ac.jp/records/2790
• Web Site: http://id.ndl.go.jp/bib/8816248
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8816248
• Web Site: https://search.jamas.or.jp/link/ui/2007329822
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed