Anti-Stress Effect of BRAND'S Essence of Chicken (BEC) on Plasma Glucose Levels in Mice Loaded with Restraint Stress

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  • Kurihara Hiroshi
    Institute of Traditional Chinese Medicine and Natural Products, Jinan University
  • Yao Xin-Sheng
    Institute of Traditional Chinese Medicine and Natural Products, Jinan University
  • Nagai Hajime
    BRAND'S Centre for Health and Nutritional Sciences, Cerebos Pacific Ltd.
  • Tsuruoka Nobuo
    Institute for Health Care Science, Research Center, Suntory Ltd.
  • Shibata Hiroshi
    Institute for Health Care Science, Research Center, Suntory Ltd.
  • Kiso Yoshinobu
    Institute for Health Care Science, Research Center, Suntory Ltd.
  • Fukami Harukazu
    Department of Bioscience and Biotechnology, Faculty of Bioenviromental Science, Kyotogakuen University

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Abstract

We investigated the effect of BRAND'S Essence of Chicken (BEC) on the basic metabolism of blood glucose in mice loaded with restraint stress. In the glucose intravenously treated mice, the stress prolonged the half-life period (T1/2) of elimination for blood glucose from 51.7 to 62.2 min. The elimination rate decreased to 82.5% per min in stressed mice compared with a starved control. The T1/2 of blood glucose was 55.2 min in the BEC treated group. BEC alleviated a stress-induced decrease in blood glucose. The improved glucose metabolism was well explained by the findings that insulin levels were elevated and glycogen synthesis in liver was remarkably activated by BEC. Our study demonstrates that BEC improves metabolic dysfunction of blood glucose by elevating insulin levels reduced by restraint stress. <br>

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