Ecotoxicological Effect of Polycyclic Musks on Caenorhabditis elegans

DOI IR HANDLE Web Site Web Site 40 References
  • Mori Taiki
    Graduate School of Science and Technology, Nagasaki University
  • Morita Fumiyo
    Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
  • Inokuchi Ayako
    Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
  • Takao Yuji
    Graduate School of Science and Technology, Nagasaki University
  • Kohra Shinya
    Graduate School of Science and Technology, Nagasaki University
  • Tominaga Nobuaki
    Department of Chemical and Biological Engineering, Ariake National College of Technology
  • Takemasa Takehiro
    Graduate School of Science and Technology, Nagasaki University
  • Arizono Koji
    Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto

Search this article

Abstract

The polycyclic musks (PCMs), 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphtha-lene (AHTN) and 1,3,4,6,7,8-hexahydro-4,6,6,7,8-hexamethylcyclopenta-γ-2-benzopyran (HHCB), are widely used as fragrance compounds in laundry detergents, soaps and cosmetics. To assess the potential toxicological effects associated with AHTN and HHCB, Caenorhabditis elegans (C. elegans) was used as a model organism for eco-toxicity testing. We examined acute toxicity using 50% lethal concentrations (LC50) after 24 hr PCM exposure and also examined changes in the test endpoints of growth and maturation such as body length, percentage of gravid worms and fecundity. The LC50 for C. elegans was found to be more than 255.2 mg/l for AHTN and 194.6 mg/l for HHCB. In growth tests, the lowest observed effect concentrations (LOEC) in C. elegans for AHTN and HHCB were 12.8 mg/l and 9.8 mg/l, respectively. In maturation tests, LOECs were estimated at 6.4 mg/l for AHTN and 9.8 mg/l for HHCB. In reproduction tests, while maximum LOECs of 19.5 mg/l were observed for HHCB, concentrations of more than 25.5 mg/l were obtained for AHTN. <br>

Journal

References(40)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top