White blood cell count and risk of all-cause and cardiovascular mortality in nationwide sample of Japanese–results from the NIPPON DATA90

• Tamakoshi Koji

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Nagoya University Graduate School of Medicine

• Toyoshima Hideaki

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Nagoya University Graduate School of Medicine

• Yatsuya Hiroshi

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Nagoya University Graduate School of Medicine

• Matsushita Kunihiro

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Nagoya University Graduate School of Medicine

• Okamura Tomonori

  Department of Health Science, Shiga University of Medical Science

• Hayakawa Takehito

  Department of Public Health, Shimane University School of Medicine

• Okayama Akira

  Department of Preventive Cardiology, National Cardiovascular Center

• Ueshima Hirotsugu

  Department of Health Science, Shiga University of Medical Science

• The NIPPON DATA90 Research Group

  Investigators of the research group are listed in Appendix

書誌事項

タイトル別名

• White Blood Cell Count and Risk of All-Cause and Cardiovascular Mortality in Nationwide Sample of Japanese
• Results From the NIPPON DATA90

抄録

Background The association of white blood cell (WBC) count with all-cause and cardiovascular disease (CVD) mortality were examined in the National Integrated Project for Prospective Observation of Non-communicable Disease and Its Trends in the Aged (NIPPON DATA) 90. Methods and Results A total of 6,756 Japanese residents (2,773 men and 3,983 women) throughout Japan without a history of CVD were followed for 9.6 years. A Cox proportional hazards regression model was used to estimate the relative risk (RR) and 95% confidence interval (CI). We documented 576 deaths with 161 deaths from CVD. Overall, after adjusting for several confounders including age, sex, body mass index at baseline, smoking status, alcohol consumption, regular exercise, diastlic blood pressure, total cholesterol, high-density lipoprotein-cholesterol and hemoglobin A1c, a graded association between WBC count and higher risk of all-cause mortality was observed (WBC of 9,000-10,000 cells/mm³ vs WBC of 4,000-4,900: RR =1.61, 95% CI: 1.07-2.40, p for trend =0.02). Elevated WBC count was almost significantly associated with high risk of CVD mortality (WBC of 9,000-10,000 vs WBC of 4,000-4,900: RR =1.79, 95% CI: 0.97-3.71). These associations strengthened among women. Stratified by smoking status, never-smokers with WBC counts of 9,000-10,000 had a 3.2 fold elevated risk for CVD death compared with those with WBC counts of 4,000-4,900. Conclusions The WBC count may have potential as a predictor for all-cause mortality, particularly CVD mortality. (Circ J 2007; 71: 479 - 485)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 71 (4), 479-485, 2007

  一般社団法人 日本循環器学会

キーワード

• Cardiovascular disease
• Mortality
• White blood cell count

詳細情報

• CRID: 1390282680078566784
• NII論文ID: 110006272134
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.71.479
• COI: 1:STN:280:DC%2BD2s7ot12ruw%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• PubMed: 17384446
• Web Site: https://www.jstage.jst.go.jp/article/circj/71/4/71_4_479/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007253390
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可