Growth-stimulating Effect of Kallikrein on Rat Neural Stem Cells : II. Immunocytochemical Analysis and Specificity of the Enzyme for Neural Stem Cells

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Author(s)

    • 木付 和幸 KIZUKI Kazuyuki
    • 山口東京理科大学、基礎工学部、物質・環境工学科 Department of Materials Science and Environmental Engineering, Faculty of Science and Engineering, Tokyo University of Science
    • 岩館 寛大 IWADATE Hiromoto
    • 山口東京理科大学、基礎工学部、物質・環境工学科 Department of Materials Science and Environmental Engineering, Faculty of Science and Engineering, Tokyo University of Science
    • 大久保 隆一 OOKUBO Ryuuichi
    • 山口東京理科大学、基礎工学部、物質・環境工学科 Department of Materials Science and Environmental Engineering, Faculty of Science and Engineering, Tokyo University of Science

Abstract

  In a previous paper we reported a new function of tissue kallikrein: rat urinary kallikrein (RUK) has a marked growth-stimulatory effect on neural stem cells prepared from brains of prenatal rats. We here report that conspicuous differentiation of neural stem cells to neurons and/or glial cells did not occur during stimulation by kallikrein, and this growth-stimulating effect of kallikrein is considerably specific for neural stem cells, <i>i.e</i>., RUK showed no detectable stimulatory effect on rat glial, PC12, GH<sub>3</sub>, and HeLa cells. Thus this new function of kallikrein suggests the potential involvement of this enzyme on brain physiology. In addition, this effect of kallikrein for neural stem cells may have value in the treatment of cerebral ischemic stroke-induced injuries <i>etc</i>., <i>i.e</i>., kallikrein administered into the body stimulates neural stem cell proliferation and new neurons may be generated from them.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 127(5), 919-922, 2007-05-01

    The Pharmaceutical Society of Japan

References:  11

Codes

  • NII Article ID (NAID)
    110006273938
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00316903
  • NDL Article ID
    8813390
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJP  NDL  NII-ELS  J-STAGE 
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