Controlled Release of Simvastatin Acid Using Cyclodextrin Inclusion System

• YOSHINARI Masao

  Oral Health Science Center HRC7, Tokyo Dental College Department of Dental Materials Science, Tokyo Dental College

• MATSUZAKA Kenichi

  Oral Health Science Center HRC7, Tokyo Dental College Department of Clinical Pathophysiology, Tokyo Dental College

• HASHIMOTO Sadamitsu

  Oral Health Science Center HRC7, Tokyo Dental College Department of Pathology, Tokyo Dental College

• ISHIHARA Kazuyuki

  Oral Health Science Center HRC7, Tokyo Dental College Department of Microbiology, Tokyo Dental College

• INOUE Takashi

  Oral Health Science Center HRC7, Tokyo Dental College Department of Clinical Pathophysiology, Tokyo Dental College

• ODA Yutaka

  Department of Dental Materials Science, Tokyo Dental College

• IDE Takaharu

  Department of Oral Anatomy and Cell Biology, Graduate School of Dental Sciences, Kyushu University

• TANAKA Teruo

  Department of Oral Anatomy and Cell Biology, Graduate School of Dental Sciences, Kyushu University

Abstract

Simvastatin acid (SVA) has been reported to stimulate bone formation by increasing expression of BMP-2 in osteoblasts. Due to their multi-functional characteristics and bioadaptability, cyclodextrins (CDs) are capable of forming inclusion complexes with many drugs by including a whole drug molecule inside their cavity. In the present study, we prepared SVA/CD inclusion complex solutions with different pH values. These were then used to determine their SVA release behavior after coating on titanium substrates, as well as to clarify the characteristics of SVA/CD complexes per se. Results showed that the lower the pH value of the solution, the lower the release kinetics of SVA. Besides, the amount of crystalline complexes in the coatings increased with decrease in pH. These results suggested that the release rate of SVA depended on two factors: pH of the solution and concomitant crystallinity of the coating.

Journal

• Dental Materials Journal

  Dental Materials Journal 26 (3), 451-456, 2007

  The Japanese Society for Dental Materials and Devices

Keywords

• Simvastatin acid
• Cyclodextrin derivative
• Controlled drug release

Details

• CRID: 1390282679692600448
• NII Article ID: 110006278340
• NII Book ID: AA10443149
• DOI: 10.4012/dmj.26.451
• COI: 1:CAS:528:DC%2BD2sXptFGmur4%3D
• ISSN: 18811361
• ISSN: 02874547
• PubMed: 17694757
• Web Site: https://www.jstage.jst.go.jp/article/dmj/26/3/26_3_451/_pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10745020
• Web Site: https://search.jamas.or.jp/link/ui/2008047834
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • NDL-Digital
  • CiNii Articles
• Abstract License Flag: Disallowed