Resveratrol oligomers from Vitis amurensis attenuate β-amyloid-induced oxidative stress in PC12 cells
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- Jang Moon Hee
- College of Pharmacy, Seoul National University
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- Piao Xiang Lan
- School of Pharmaceutical Sciences, Peking University
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- Kim Hyun Young
- College of Pharmacy, Seoul National University
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- Cho Eun Jung
- College of Pharmacy, Seoul National University
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- Baek Seung Hoon
- College of Pharmacy, Seoul National University
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- Kwon Sung Won
- College of Pharmacy, Seoul National University
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- Park Jeong Hill
- College of Pharmacy, Seoul National University
書誌事項
- タイトル別名
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- Resveratrol Oligomers from Vitis amurensis Attenuate .BETA.-Amyloid-Induced Oxidative Stress in PC12 Cells
- Resveratrol oligomers from Vitis amurensis attenuate b amyloid induced oxidative stress in PC12 cells
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抄録
Oxidative damage induced by β-amyloid (Aβ) is closely associated with the hallmark pathologies of Alzheimer's disease (AD) and may play a critical role in the development of AD. In this study, the protective effects of vitisin A and heyneanol A, resveratrol oligomers isolated from Vitis amurensis RUPR. (Vitaceae), against Aβ-induced oxidative cell death were investigated using rat pheochromocytoma (PC12) cells. Exposure of PC12 cells to the Aβ (20 μM) for 24 h resulted in neuronal cell death, whereas pretreatment with vitisin A or heyneanol A at the concentration range of 5—50 μM reduced Aβ-induced cell death. In addition, Aβ-induced elevation of reactive oxygen species generation, the primary cause of Aβ-induced oxidative stress, was attenuated by treatment of vitisin A or heyneanol A (10, 25, 50 μM). Aβ-treated cells also displayed characteristic features of apoptosis such as induction of DNA fragmentation and caspase-3 activation, but vitisin A and heyneanol A (10, 50 μM) significantly suppressed these events. These results suggest that vitisin A and heyneanol A prevent Aβ-induced neurotoxicity through attenuating oxidative stress induced by Aβ, and may be useful as potential preventive or therapeutic agents for AD.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 30 (6), 1130-1134, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679602185856
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- NII論文ID
- 110006278404
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BD2szivVCjtQ%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 8741477
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- PubMed
- 17541166
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可