Comparative Study of Circadian Variation in Numbers of Peripheral Blood Cells among Mouse Strains: Unique Feature of C3H/HeN Mice

• Ohkura Naoki

  Clinical Molecular Biology, Faculty of Pharmaceutical Sciences, Teikyo University

• Oishi Katsutaka

  Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology

• Sekine Yuji

  Clinical Molecular Biology, Faculty of Pharmaceutical Sciences, Teikyo University

• Atsumi Gen-ichi

  Clinical Molecular Biology, Faculty of Pharmaceutical Sciences, Teikyo University

• Ishida Norio

  Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology

• Matsuda Juzo

  Clinical Molecular Biology, Faculty of Pharmaceutical Sciences, Teikyo University

• Horie Shuichi

  Department of Clinical Biochemistry, Kagawa Nutrition University

Abstract

We examined strain differences in numbers of blood cells and their circadian rhythms in male Jcl:ICR, BALB/cA, C57BL/6J and C3H/HeN mice. The total numbers of circulating white blood cells (WBCs) were increased during subjective day and night, and the peaks in the active period were common to all strains. However, the number of WBCs in C3H/HeN mice remained lower and plasma levels of corticosterone (CS) were slightly higher throughout the day compared with the other strains. The numbers of circulating red blood cells (RBC) also differed according to strain. The numbers of RBCs, hematocrit (HCT) and hemoglobin (HGB) were considerably lower in C3H/HeN mice compared with the other strains, although mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV) were highest among the tested strains. We found that serum erythropoetin (EPO) levels were considerably higher in C3H/HeN mice than in the other three strains. The high EPO level might be related to the unique features of RBCs in C3H/HeN mice. The present observations provide basic information about the numbers of peripheral blood cells and their circadian rhythm in mouse models and also demonstrate a unique feature of C3H/HeN mice.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 30 (6), 1177-1180, 2007

  The Pharmaceutical Society of Japan

Keywords

• blood cell
• circadian
• difference
• erythropoetin
• mouse
• strain

Details

• CRID: 1390001204625520640
• NII Article ID: 110006278416
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.30.1177
• COI: 1:STN:280:DC%2BD2szivVCiuw%3D%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 8741641
• Web Site: http://id.ndl.go.jp/bib/8741641
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8741641
• Web Site: http://www.jstage.jst.go.jp/article/bpb/30/6/30_6_1177/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007301696
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed