Steric and electronic effects of methyl substitutents at the 2- and 6-positions on N-benzyl-1,4-dihydronicotinamide.

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Abstract

<I>N</I>-Benzyl-1, 4-dihydronicotinamides having 2-methyl, 6-methyl and 2, 6-dimethyl substituents were prepared and their reactivities toward an activated carbonyl compound (hexachloroacetone) were investigated. The reaction rates were especially enhanced for the 2, 6-dimethyl derivative, with the order of the rates being 2, 6-dimethyl>2-methyl>6-methyl. The steric and electronic effects of the methyl group (s) are discussed based on the ultraviolet spectra and redox potential data.

Journal

  • Chemical and Pharmaceutical Bulletin

    Chemical and Pharmaceutical Bulletin 35(7), 2661-2667, 1987

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    110006281306
  • NII NACSIS-CAT ID (NCID)
    AA00602100
  • Text Lang
    ENG
  • ISSN
    0009-2363
  • Data Source
    NII-ELS  J-STAGE 
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