Inhibitiory activities of proanthocyanidins from persimmon against oxidative stress and digestive enzymes related to diabetes
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- LEE Young A
- Institute of Natural Medicine, University of Toyama
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- CHO Eun Ju
- Department of Food Science and Nutrition, Pusan National University
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- TANAKA Takashi
- Graduate School of Biomedical Sciences, Nagasaki University
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- YOKOZAWA Takako
- Institute of Natural Medicine, University of Toyama
書誌事項
- タイトル別名
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- Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes
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抄録
The present study was carried out to evaluate the promising potential of polymers and oligomers from proanthocyanidins of persimmon peel as antioxidants and therapeutic agents for diabetes. Both polymers and oligomers showed the scavenging effect of 2,2-diphenyl-1-picrylhydrazyl, with IC50 values of 4.35 and 2.41 μg/mL, respectively, and they also showed a protective activity against protein oxidation induced by 2,2'-azobis (2-amidinopropane) dihydrochloride. In particular, oligomers exerted a stronger activity against free radicals than polymers. In addition, to investigate their protective potential against diabetes-related pathological conditions, their inhibitory activities on digestive enzymes and advanced glycation endproduct (AGE) formation were evaluated. Polymers showed a strong inhibitory activity against α-amylase, while oligomers had a relatively weak effect. This suggests that the inhibition of α-amylase activity would probably depend on the degree of polymerization. On the other hand, against α-glucosidase activity and AGE formation, oligomers exerted a stronger protective effect than polymers. The present study suggests that polymers and oligomers from proanthocyanidins of persimmon peel could play a role as antidiabetic agents with antioxidative effects. Moreover, oligomers rather than polymers from proanthocyanidins of persimmon peel may be expected to be a more promising antioxidative and antidiabetic agent in relation to utilization in biological systems.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 53 (3), 287-292, 2007
一般財団法人 学会誌刊行センター
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詳細情報
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- CRID
- 1390282681302334976
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- NII論文ID
- 110006317290
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD2sXns1OmtL8%3D
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- ISSN
- 18817742
- 03014800
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- HANDLE
- 10069/18972
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- NDL書誌ID
- 8785844
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- PubMed
- 17874835
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可