Mechanism and New Findings in Brugada Syndrome

DOI Web Site 被引用文献4件 参考文献58件
  • Shimizu Wataru
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
  • Aiba Takeshi
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
  • Kamakura Shiro
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center

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Brugada syndrome is a clinical entity characterized by coved type ST-segment elevation in the right precordial electrocardiographic leads (V1-3) and an episode of ventricular fibrillation in the absence of structural heart disease. Although a number of clinical and experimental reports have elucidated the electrocardiographic, electrophysiologic, cellular, and molecular aspects, several problems remain unsolved. Recently developed high-resolution optical mapping techniques in arterially-perfused wedge preparations enable recording of transmembrane action potentials from 256 sites simultaneously at the epicardial surface, thus providing further advances in the understanding of the cellular mechanism of the specific ST-segment elevation and subsequent ventricular arrhythmias. In this review article, new findings relating to several unresolved problems such as gender difference (male predominance) and ethnic difference (higher incidence in Asian population) are also presented. (Circ J 2007; Suppl A: A-32 - A-39)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 71 (SupplementA), A32-A39, 2007

    一般社団法人 日本循環器学会

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