Antifungal activity of the saponin fraction obtained from Asparagus officinalis L. and its active principle.

• SHIMOYAMADA Makoto

  Department of Food Chemistry, Faculty of Agriculture, Tohoku University

• SUZUKI Masayuki

  Central Research Laboratory, Dowa Mining Co., Ltd.

• SONTA Hiromi

  Central Research Laboratory, Dowa Mining Co., Ltd.

• MARUYAMA Makiko

  Central Research Laboratory, Dowa Mining Co., Ltd.

• OKUBO Kazuyoshi

  Department of Food Chemistry, Faculty of Agriculture, Tohoku University

抄録

Antifungal activity was detected in the crude saponin fraction obtained from the bottom cut of Asparagus officinalis L. This activity was specific to certain fungi, for example Candida, Cryptococcus, Trichophyton, Microspomm and Epidermophyton. Attempts were made to isolate the active principles from this fraction; in this way a new saponin (AS-1) was isolated, and its structure was estimated to be 3-O-[{β-D-glucopyranosyl(1 →2)}{β-D-xylopyranosyl(1→4)-β-D-glucopyranosyl]-(25S), 5β-spirostan-3β-ol. The minimum inhibitory concentration (MIC) ranged from 0.5μg/ml to more than 8μg/ml depending upon the nature of the fungi. On the basis of the work carried out here, it is probable that asparagus will contain additional antifungal principles.

収録刊行物

• Agricultural and Biological Chemistry

  Agricultural and Biological Chemistry 54 (10), 2553-2557, 1990

  公益社団法人 日本農芸化学会

キーワード

• General Agricultural and Biological Sciences
• General Biochemistry, Genetics and Molecular Biology

詳細情報

• CRID: 1390001206460973952
• NII論文ID: 110006324604
• NII書誌ID: AA00515312
• DOI: 10.1271/bbb1961.54.2553
• ISSN: 18811280
• ISSN: 00021369
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可