Effect of prednisolone on the urinary excretion of nicotinamide and its metabolites in rats fed with a niacin-free diet.

• SHIBATA Katsumi

  Department of Food Science and Nutrition, Teikoku Women's University

抄録

Adrenal cortical hormone seems to play an important role in de novo NAD biosynthesis from tryptophan. Therefore, the effects of prednisolone, a synthetic adrenal cortical hormone, on the urinary excretion of nicotinamide and such catabolic metabolites as N¹-methyhiicotinamide (MNA), N¹-methyl-2-pyridone-5-carboxamide (2-Py) and N¹-methyl-4-pyridone-3-carboxamide (4-Py) were investigated. Rats fed with a niacin-free diet were intraperitoneally injected with prednisolone (3mg/rat) three times at 09:00, 13:00 and 17:00 hr on day 0. As a result, the urinary excretion of nicotinamide, MNA, 2-Py and 4-Py was each higher in the prednisolone group than in the physiological saline group (for control) after 1 day; however, each excretion was lower in the prednisolone group than in control group after 3, 4, 5 and 6 days. On around the 7th day, the urinary excretion in the prednisolone group was restored to the control values. The initial rapid increase and subsequent decrease in the urinary excretion of nicotinamide and its metabolites by an injection of prednisolone is considered to be attributable to a respective elevation of the liver tryptophan oxygenase level and the liver aminocarboxymuconate-semialdehyde decarboxylase level.

収録刊行物

• Agricultural and Biological Chemistry

  Agricultural and Biological Chemistry 54 (5), 1195-1200, 1990

  公益社団法人 日本農芸化学会

キーワード

• General Agricultural and Biological Sciences
• General Biochemistry, Genetics and Molecular Biology

詳細情報

• CRID: 1390282681440545664
• NII論文ID: 110006324921
• NII書誌ID: AA00515312
• DOI: 10.1271/bbb1961.54.1195
• COI: 1:CAS:528:DyaK3cXktlCrtbw%3D
• ISSN: 18811280
• ISSN: 00021369
• Web Site: https://search.jamas.or.jp/link/ui/1991172463
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可