Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed I. Optimum Formulation for Core Particles and Development of a Novel Friability Test Method
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- Hamashita Tomohiro
- Oral Solid Formulation Laboratory, Self Medication Laboratories, Taisho Pharmaceutical Co., Ltd.
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- Nakagawa Yasuo
- Oral Solid Formulation Laboratory, Self Medication Laboratories, Taisho Pharmaceutical Co., Ltd.
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- Aketo Takao
- Oral Solid Formulation Laboratory, Self Medication Laboratories, Taisho Pharmaceutical Co., Ltd.
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- Watano Satoru
- Department of Chemical Engineering, Osaka Prefecture University
Bibliographic Information
- Other Title
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- Granulation of core particles suitable for film coating by agitation fluidized bed (1) Optimum formulation for core particles and development of a novel friability test method
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Abstract
To prepare powdered medicines without bitter taste, film coating is required to cover the surface of core particles. In this study, effect of formulation and operating conditions of agitation fluidized bed on the core particle properties was investigated. In order to prevent breakage of the core particles during coating process, which sometimes causes variation of drug dissolution rate, addition of maltose syrup powder during the formulation process of the core particles was investigated. Also, a method for friability test in which the core particles were subjected to strong impact was proposed to evaluate strength of the core particles. The friability of the core particles determined by this test method correlated well with the actual friability of the particles during the coating process. Based on this result, we confirmed this novel friability test method could predict the core particle endurance during the coating process.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 55 (8), 1169-1174, 2007
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204168392960
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- NII Article ID
- 110006366534
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 8824568
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed