成人生体肝移植患者におけるタクロリムス血中濃度の経時的推移ならびに肝機能検査値との相関性について
書誌事項
- タイトル別名
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- Relationship between Blood Concentrations of Tacrolimus and Liver Biochemical Profiles in Adult Living-Donor Liver Transplantation Recipients
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The purpose of this study was to investigate the relationship between blood concentrations of tacrolimus and liver biochemical profiles in living-donor liver transplantation recipients.The results indicated that the tacrolimus blood concentration/dose ratio (C/D ratio) decreased following living-donor liver transplantation.Furthermore,the variation in the C/D ratio and tacrolimus blood concentration was greater at 1 week after surgery than at 2-4 weeks afterwards.We also noted that when the C/D ratio was high total bilirubin was also high,suggesting that a low dosage of tacrolimus is necessary for hightotal bilirubin patients.However,there was no definite correlation between AST or ALT and the C/D ratio.It is therefore necessary to control tacrolimus blood concentrations in adult living-donor liver transplantation recipients.
収録刊行物
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- 医療薬学
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医療薬学 33 (8), 674-679, 2007
一般社団法人日本医療薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204776453120
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- NII論文ID
- 110006367052
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- NII書誌ID
- AA11527197
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- ISSN
- 18821499
- 1346342X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可