Synthetic Osteopontin-derived Peptide SVVYGLR can Induce Neovascularization in Artificial Bone Marrow Scaffold Biomaterials

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Author(s)

    • HAMADA Yoshinosuke
    • Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
    • EGUSA Hiroshi
    • Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry
    • KANEDA Yoshitoshi
    • Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry
    • HIRATA Isao
    • Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
    • KAWAGUCHI Naomasa
    • Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
    • HIRAO Takafumi
    • Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
    • MATSUMOTO Takuya
    • Division of Oromaxillofacial Regeneration, Course for Integrated Oral Sciences and Stomatology, Osaka University Graduate School of Dentistry
    • YAO Makiko
    • Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
    • SUZUKI Mayuka
    • Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
    • YATANI Hirofumi
    • Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry
    • OKAZAKI Masayuki
    • Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry
    • MATSUURA Nariaki
    • Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science

Abstract

We have previously reported that an osteopontin-derived SVVYGLR peptide exhibited potent angiogenic activity <i>in vitro</i> and <i>in vivo</i>. In the present study, the focus points were on the <i>in vitro</i> effect of SVVYGLR on bone marrow stromal cell proliferation, as well as its <i>in vivo</i> effect on bone tissue formation when grafts made of CO<sub>3</sub>Ap-collagen sponge—as a scaffold biomaterial containing the SVVYGLR motif—were implanted. SVVYGLR peptide promoted bone marrow stromal cell proliferation. When a CO<sub>3</sub>Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells—as well as prominent angiogenesis—inside the graft could be detected after one week. These results thus suggested that our scaffold biomaterials including the peptide could be useful for bone tissue regeneration.

Journal

  • Dental Materials Journal

    Dental Materials Journal 26(4), 487-492, 2007-07-01

    The Japanese Society for Dental Materials and Devices

References:  17

Cited by:  5

Codes

  • NII Article ID (NAID)
    110006368707
  • NII NACSIS-CAT ID (NCID)
    AA10443149
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    02874547
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE  NDL-Digital 
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