Decreased Lipoprotein Lipase in Obstructive Sleep Apnea Syndrome

• Iesato Ken

  Department of Respirology, Graduate School of Medicine, Chiba University

• Tatsumi Koichiro

  Department of Respirology, Graduate School of Medicine, Chiba University

• Saibara Toshiji

  Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University

• Nakamura Akira

  Department of Respirology, Graduate School of Medicine, Chiba University

• Terada Jiro

  Department of Respirology, Graduate School of Medicine, Chiba University

• Tada Yuji

  Department of Respirology, Graduate School of Medicine, Chiba University

• Sakao Seiichiro

  Department of Respirology, Graduate School of Medicine, Chiba University

• Tanabe Nobuhiro

  Department of Respirology, Graduate School of Medicine, Chiba University

• Takiguchi Yuichi

  Department of Respirology, Graduate School of Medicine, Chiba University

• Kuriyama Takayuki

  Department of Respirology, Graduate School of Medicine, Chiba University

抄録

Background Lipoprotein lipase (LPL) might play a major role in lipid metabolism by hydrolyzing triglyceride-rich lipoproteins. Decreased LPL activity can trigger early inflammatory responses central to atherosclerosis. However, whether repeated apnea-related hypoxemia influences lipid metabolism in patients with obstructive sleep apnea syndrome (OSAS) remain undefined. This investigation determined whether circulating LPL was influenced by repeated apnea-related hypoxemia, and the effect of nasal continuous positive airway pressure (CPAP) therapy on LPL concentrations in OSAS patients. Methods and Results The participants of the study were 155 men with OSAS and 39 men without OSAS. Circulating LPL concentrations decreased with the severity of OSAS. They correlated negatively with serum triglyceride, and the linear regression lines between LPL concentrations and triglyceride in OSAS patients were shifted downward compared with those in non-OSAS patients, suggesting that any pathophysiological factor might decrease LPL activity in OSAS patients. Some OSAS patients were subjected to CPAP therapy for 3 months. CPAP therapy increased LPL concentrations and decreased C-reactive protein (CRP) concentrations. Conclusions The present study suggests that repeated apnea-related hypoxemia might affect lipid metabolism and augment inflammatory responses, and CPAP therapy could be effective to decrease inflammatory responses and ameliorate lipid metabolism in patients with OSAS. (Circ J 2007; 71: 1293 - 1298)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 71 (8), 1293-1298, 2007

  一般社団法人 日本循環器学会

キーワード

• Atherosclerosis
• Inflammation
• Lipid metabolism
• Sleep apnea

詳細情報

• CRID: 1390282680081113088
• NII論文ID: 110006368859
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.71.1293
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/71/8/71_8_1293/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008033343
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可