Rubusuaviins A-F, Monomeric and Oligomeric Ellagitannins from Chinese Sweet Tea and Their α-Amylase Inhibitory Activity

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Six new ellagitannins herein, rubusuaviins A?F, were isolated from the aqueous acetone extract of Chinese sweet tea (Tien-cha, dried leaves of Rubus suavissimus S. LEE) together with seven known tannins. Rubusuaviin A was characterized as 1-O-galloyl-2,3-O-(S)-HHDP-4,6-O-(S)-sanguisorboyl-β-D-glucopyranose. Rubusuaviins B, C, and E are dimeric, trimeric, and tetrameric ellagitannins, respectively, in which the sanguisorboyl groups were connected ellagitannin units. Rubusuaviins D and F were desgalloyl derivatives of rubusuaviins C and E, respectively. The inhibition of α-amylase activity by rubusuaviins and related ellagitannins was compared. Ellagitannins with β-galloyl groups at the glucose C-1 positions showed stronger inhibition compared with the α-galloyl and desgalloyl compounds. The molecular weight of these compounds was not important for the inhibition of α-amylase activity.

Six new ellagitannins herein, rubusuaviins A—F, were isolated from the aqueous acetone extract of Chinese sweet tea (Tien-cha, dried leaves of <i>Rubus suavissimus</i> S. L<small>EE</small>) together with seven known tannins. Rubusuaviin A was characterized as 1-<i>O</i>-galloyl-2,3-<i>O</i>-(<i>S</i>)-HHDP-4,6-<i>O</i>-(<i>S</i>)-sanguisorboyl-β-<small>D</small>-glucopyranose. Rubusuaviins B, C, and E are dimeric, trimeric, and tetrameric ellagitannins, respectively, in which the sanguisorboyl groups were connected ellagitannin units. Rubusuaviins D and F were desgalloyl derivatives of rubusuaviins C and E, respectively. The inhibition of α-amylase activity by rubusuaviins and related ellagitannins was compared. Ellagitannins with β-galloyl groups at the glucose C-1 positions showed stronger inhibition compared with the α-galloyl and desgalloyl compounds. The molecular weight of these compounds was not important for the inhibition of α-amylase activity.

収録刊行物

  • Chemical & pharmaceutical bulletin

    Chemical & pharmaceutical bulletin 55(9), 1325-1331, 2007-09-01

    公益社団法人日本薬学会

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各種コード

  • NII論文ID(NAID)
    110006379652
  • NII書誌ID(NCID)
    AA00602100
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00092363
  • NDL 記事登録ID
    8877606
  • NDL 雑誌分類
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-D167
  • データ提供元
    CJP書誌  CJP引用  NDL  NII-ELS  IR  J-STAGE 
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